摘要
目的探讨基于中医“调升降,解伏火”论治儿童变应性咳嗽的效果。方法纳入儿童变应性咳嗽患者123例,随机分成观察组1、观察组2及对照组,每组41例。观察组1采取清金定喘颗粒治疗,观察组2采取清金定喘颗粒联合孟鲁司特钠治疗,对照组采取孟鲁司特钠治疗。对比各组患者治疗前后中医症候分级量化表评分、血清总免疫球蛋白E(IgE)、嗜酸性粒细胞(EOS)、第一秒用力呼气容积(FEV1)、用力肺活量(FVC)、呼气峰值流速(PEF)变化,统计不良反应发生情况。结果实验结果表明,干预后三组患者的主要与次要症状评分、血清总IgE和嗜酸性粒细胞水平均较治疗前显著下降,且观察组2的降幅最大,其次为观察组1,对照组最小,各组间差异均具有统计学意义(P<0.05)。在肺功能改善方面,三组患者FEV1、FVC和PEF指标均较基线水平显著提高,其中观察组2的提升幅度最大,观察组1次之,对照组最小,组间差异均达到统计学显著水平(P<0.05)。三组治疗期间不良反应率对比差异无统计学意义(P>0.05)。结论基于中医“调升降,解伏火”论治儿童变应性咳嗽效果满意,可降低IgE与EOS水平,减轻咳嗽症状及改善肺功能,且安全性较高,值得推广应用。
Objective To explore the effect of traditional Chinese medicine's“regulating the rise and fall,relieving the hidden fire”theory in treating allergic cough in children.Method 123 children with allergic cough were included and randomly divided into observation group 1,observation group 2,and control group,with 41 cases in each group.Observation group 1 was treated with Qingjin Dingchuan granules,observation group 2 was treated with Qingjin Dingchuan granules combined with Montelukast sodium,and the control group was treated with Montelukast sodium.Compare the changes in Traditional Chinese Medicine Syndrome Grading Scale scores,serum total immunoglobulin E(IgE),eosinophils(EOS),forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and peak expiratory flow rate(PEF)before and after treatment in each group of patients,and record the occurrence of adverse reactions.Results The experimental results showed that the main and secondary symptom scores,serum total IgE,and eosinophil levels of the three groups of patients significantly decreased after intervention compared to before treatment,with observation group 2 showing the largest decrease,followed by observation group 1,and the control group showing the smallest decrease.The differences between the groups were statistically significant(P<0.05).In terms of improving lung function,the FEV1,FVC,and PEF indicators of the three groups of patients were significantly increased compared to baseline levels,with observation group 2 showing the largest increase,followed by observation group 1,and the control group showing the smallest increase.The differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions among the three treatment groups(P>0.05).Conclusion The treatment of allergic cough in children based on the traditional Chinese medicine theory of“regulating the rise and fall,relieving internal heat”has a satisfactory effect,can reduce IgE and EOS levels,alleviate cough symptoms and improve lung function,and has high safety.It is worth promoting and applying.
作者
张翔
王琦越
唐镕
Zhang Xiang;Wang Qiyue;Tang Rong(Department of Pediatrics,Jinniu District Traditional Chinese Medicine Hospital,Chengdu 610000,Sichuan)
出处
《当代临床医刊》
2025年第4期110-113,共4页
Journal of Contemporary Clinical Medicine
基金
四川省中医药管理局科学技术研究专项课题,编号:2023MS151。
关键词
儿童
变应性咳嗽
调升降
解伏火
临床疗效
Children
Allergic cough
Adjust the lift
Relieve the hidden fire
clinical efficacy
