摘要
Toll样受体3(Toll-like receptor 3,TLR3)在寨卡病毒(Zika virus,ZIKV)感染介导的炎症反应及神经损伤中具有重要作用,然而,ZIKV感染TLR3基因敲除小鼠模型的开发相对滞后,其应用潜力尚未被充分挖掘。因此,建立合适的动物感染模型对解析ZIKV致病机制及研发防治策略具有重要意义。本研究成功建立并验证了TLR3-KO小鼠模型,该模型在寨卡病毒系统性感染特征、组织病理损伤模式及免疫应答特征方面均展现出良好的实验适用性,为探究寨卡病毒致病分子机制及抗病毒药物研发提供了可靠的动物实验平台。
Toll-like receptor 3(TLR3)plays a crucial role in the inflammatory responses and neural damage asso-ciated with Zika virus(ZIKV)infection.However,the development of ZIKV infection models utilizing TLR3 gene knockout mice has been relatively delayed,and their potential applications remain inadequately explored.Therefore,es-tablishing appropriate animal infection models is significantly important for elucidating the pathogenic mechanisms of ZIKV and for developing effective prevention and treatment strategies.In this study,we successfully established and vali-dated a TLR3 knockout(KO)mouse model.This model demonstrates excellent experimental applicability regarding sys-temic infection characteristics,histopathological damage patterns,and immune response features of ZIKV,thereby pro-viding a reliable platform for in-depth exploration of the molecular mechanisms underlying ZIKV pathogenesis and the de-velopment of antiviral drugs.
作者
蔡曾
鲜巧阳
苏珊
龙子文
张璋
汤宏斌
Cai Zeng;Xian Qiaoyang;Su Shan;Long Ziwen;Zhang Zhang;Tang Hongbin(Center for Animal Experiment/ABSL-III Laboratory,Wuhan University,Wuhan 430062,Hubei,China)
出处
《生物资源》
2025年第4期324-329,共6页
Biotic Resources
基金
国家重点研发计划(2021YFF0702002)
湖北省自然科学基金青年项目(2024AFB103)。
