摘要
多囊卵巢综合征(PCOS)是一种常见的内分泌和代谢紊乱疾病,近年来发病率逐年上升。其发病机制涉及遗传、胰岛素抵抗、脂代谢异常、慢性炎症、高雄激素血症、心理等多种因素相互作用,显著增加流产、妊娠并发症等风险,严重危害女性生殖健康。PCOS患者常伴随着肥胖,肥胖不仅是PCOS的重要表型特征,更是其病理进展的驱动因素。因此,减重是治疗肥胖型PCOS的首要目标。通过生活方式管理、药物治疗、代谢手术、中医药等多种方法减重,可有效改善代谢紊乱、恢复排卵功能。本综述系统阐述肥胖型PCOS患者的发病机制,论述减重治疗对其内分泌和代谢影响的相关研究,旨在为深入了解该疾病及其临床诊治提供更多思路和参考。
Polycystic ovary syndrome(PCOS)is a common endocrine and metabolic disorder,the incidence of which has been rising in recent years.The pathogenesis of this condition involves the interplay of multiple factors,including genetics,insulin resistance,lipid metabolism abnormalities,chronic inflammation,hyperandrogenemia,and psychological factors.These factors significantly increase the risk of miscarriage and pregnancy complications,resulting in a serious threat to women’s reproductive health.PCOS patients commonly have obesity.Obesity is not only a key phenotypic characteristic of PCOS,but more importantly,a driving factor in its pathological progression.Therefore,weight loss is the primary treatment goal for obese women with PCOS.Weight reduction through lifestyle management,pharmacological therapy,metabolic surgery,traditional Chinese medicine,and other methods can effectively improve metabolic disturbances and restore ovulatory function.This review systematically elaborates on the pathogenesis of obese patients with PCOS and discusses relevant research on the effects of weight reduction treatment on their endocrine and metabolic status,aiming to provide more insights and references for a deeper understanding of the disease and its clinical management.
作者
欧阳雅囡
隋娟
李艳红
王娜娜
任梦雪
陈瑞雪
OUYANG Ya-nan;SUI Juan;LI Yan-hong;Wang Na-na;REN Meng-xue;CHEN Rui-xue(Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053)
出处
《生殖医学杂志》
2025年第9期1290-1295,共6页
Journal of Reproductive Medicine
基金
国家自然科学基金(82274574)
中国中医科学院科技创新工程项目(CI2021A02407)
中国中医科学院广安门医院所级科研基金课题(2022S472)。
关键词
多囊卵巢综合征
肥胖
发病机制
减重治疗
研究进展
Polycystic ovary syndrome
Obesity
Pathogenesis
Weight reduction treatment
Research progress
