摘要
目的探讨富血小板血浆(PRP)在老年性骨质疏松患者腰椎椎间融合术中的作用。方法前瞻性选择2022年1月至2023年2月在本院行后路腰椎椎体间植骨融合术患者96例,根据随机数字表法将患者分为观察组(48例)和对照组(48例),在腰椎间融合术中,对照组植入Cage、自体骨,观察组Cage、自体骨与PRP联合植入,比较两组患者的一般资料、手术情况、治疗前后的疼痛评分、功能指数及血清学指标;采用随机行走模型评价两组患者治疗后的上述评分改善情况;比较两组患者的不良反应发生情况。结果纳入患者均顺利完成手术,未出现脊髓或神经功能损伤。观察患者的术后3个月和术后6个月的VAS评分小于对照组,差异有统计学意义(P<0.05)。手术1年后,观察组患者融合率为93.75%(45/48),高于对照组79.17%(38/48),且观察组患者的融合层数和椎间隙高度均较对照组增加,差异有统计学意义(P<0.05)。术后,两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、降钙素原(PCT)水平均低于术前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论PRP能够增加椎间植骨融合质量及融合率,临床应用效果良好,安全性满意。
Objective To investigate the role of platelet-rich plasma(PRP)in bone fusion of lumbar interbody fusion in senile osteoporosis patients.Methods 96 patients who underwent posterior lumbar interbody fusion in our hospital from January 2022 to February 2023 were prospectively selected.According to the random number table,the patients were divided into observation group(48 cases)and control group(48 cases).During lumbar interfusion,the control group was implanted with Cage and autologous bone,and the observation group was implanted with Cage and autologous bone combined with PRP.The general information,operation situation and PRP of the two groups were compared.The random walking model was used to evaluate the improvement of the above scores in the two groups after treatment.The incidence of adverse reactions between the two groups was compared.Results All patients successfully completed the operation without spinal cord or nerve function injury.The VAS scores of the observation patients at 3 months and 6 months after surgery were lower than those of the control group,and the difference was statistically significant(P<0.05).One year after surgery,the fusion rate of observation group was 93.75%(45/48),which was significantly higher than that of control group 79.17%(38/48),and the number of fusion layers and vertebral space height of observation group increased compared with control group,with statistical significance(P<0.05).After operation,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),procalcitonin(PCT)in 2 groups were lower than before operation,the observation group was lower than control group,and the difference was statistically significant(P<0.05).Conclusion PRP can improve the fusion quality and fusion rate of intervertebral bone graft,with good clinical application effect and satisfactory safety.
作者
钟学仁
席新华
包拥政
胡孔和
熊英辉
卢林俊
胡永玉
李丹
张正赟
骆影超
陈华平
谭利明
ZHONG Xueren;XI Xinhua;BAO Yongzheng;HU Konghe;XIONG Yinghui;LU Linjun;HU Yongyu;LI Dan;ZHANG Zhengyun;LUO Yingchao;CHEN Huaping;TAN Liming(Department of Spine Surgery,Yuebei People’s Hospital,Shaoguan 512026;Department of Arthropathy and Orthopedics,Yuebei People’s Hospital,Shaoguan 512026;Department of Imaging Diagnosis,Yuebei People’s Hospital,Shaoguan 512026;Department of Science and Education,Yuebei People’s Hospital,Shaoguan 512026)
出处
《颈腰痛杂志》
2025年第5期797-802,共6页
The Journal of Cervicodynia and Lumbodynia
基金
2021年度韶关市科技计划项目(210924224531627)。
关键词
富血小板血浆
椎间融合术
骨融合
骨质疏松
随机对照
随机行走模型
platelet-rich plasma
intervertebral fusion
bone fusion
osteoporosis
randomized control
random walk model
