摘要
目的探讨血红素氧合酶-1(HO-1)、可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)水平与急性缺血性脑卒中患者神经功能、认知功能的相关性。方法纳入沧州市人民医院2020年8月—2023年10月收治的105例急性缺血性脑卒中患者为病例组,另选取本院同期体检健康的85例志愿者为对照组。对比两组一般资料及血清中HO-1、sLOX-1水平;用Pearson分析法分析血清HO-1、sLOX-1水平和神经功能、认知功能的相关性。结果病例组血清HO-1、sLOX-1水平及美国国立卫生研究院卒中量表(NIHSS)和神经功能缺损评分量表(NFDS)评分均高于对照组(P<0.05);病例组蒙特利尔认知评估量表(MoCA)和简易智能状态检查量表(MMSE)评分均低于对照组(P<0.05)。病例组患者中88例出现神经功能轻度缺损,17例出现神经功能中度缺损。与对照组相比,轻度缺损组、中度缺损组HO-1、sLOX-1水平均较高(P<0.05),且中度缺损组高于轻度缺损组(P<0.05)。病例组患者中15例认知功能正常,90例认知功能障碍。与对照组相比,认知障碍组、认知正常组HO-1、sLOX-1水平均较高(P<0.05),且认知障碍组高于认知正常组(P<0.05)。与对照组相比,认知正常组、单纯认知障碍组、轻度神经缺损组、中度神经缺损组和神经功能缺损伴认知障碍组HO-1、sLOX-1水平均较高(P<0.05);与单纯认知障碍组、轻度神经缺损组及中度神经缺损组相比,神经功能缺损伴认知障碍组患者HO-1、sLOX-1水平均较高(P<0.05)。急性缺血性卒中患者血清HO-1、sLOX-1水平与NIHSS、NFDS呈正相关(P<0.05),与MoCA、MMSE呈负相关(P<0.05)。结论急性缺血性脑卒中患者血清中HO-1、sLOX-1水平及神经功能缺损评分呈高表达,认知功能评分呈低表达,血清HO-1、sLOX-1水平、神经功能、认知功能之间密切相关。
Objective To investigate the correlation of heme oxygenase-1(HO-1)and soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1)levels with neurological function and cognitive function in patients with acute ischemic stroke(AIS).Methods The case group included 105 patients with AIS in the hospital from August 2020 to October 2023,and the control group was consisted of 85 healthy volunteers who received physical examination during the same period.The general data and serum levels of HO-1 and sLOX-1 were compared between both groups.Pearson analysis was used to analyze the correlation between serum HO-1 and sLOX-1 levels and neurological function and cognitive function.Results The levels of serum HO-1 and sLOX-1,score of National Institutes of Health Stroke Scale(NIHSS)and score of Neurological Functional Deficit Scale(NFDS)in the case group were higher than those in the control group(P<0.05)while the score of Montreal Cognitive Assessment Scale(MoCA)and score of Mini-Mental State Examination(MMSE)were lower than those in the control group(P<0.05).In the case group,there were 88 cases of mild neurological deficit and 17 cases of moderate neurological deficit.Compared with the control group,the levels of HO-1 and sLOX-1 in the mild and moderate defect groups were higher(P<0.05),and the above levels in the moderate defect group were higher than those in the mild defect group(P<0.05).15 patients had normal cognitive function and 90 patients had cognitive impairment in the case group.Compared with the control group,the levels of HO-1 and sLOX-1 in normal cognitive group,simple cognitive impairment group,mild nerve deficit group,moderate nerve deficit group and nerve function deficit with cognitive impairment group were higher(P<0.05).The levels of HO-1 and sLOX-1 in patients with neurological impairment combined with cognitive impairment were higher than those in simple cognitive impairment group,mild nerve impairment group and moderate nerve impairment group(P<0.05).Serum HO-1 and sLOX-1 levels in patients with AIS were positively correlated with NIHSS and NFDS(P<0.05),but were negatively correlated with MoCA and MMSE(P<0.05).Conclusion The levels of serum HO-1 and sLOX-1 and scores of neurological deficits in patients with acute ischemic stroke are highly expressed while the cognitive function scores are lowly expressed.There is a close correlation between levels of serum HO-1 and sLOX-1 and neurological function and cognitive function.
作者
房硕
董兰真
刘洋洋
吴婧
刘桂丽
FANG Shuo;DONG Lanzhen;LIU Yangyang;WU Jing;LIU Guili(Department of Neurology,Cangzhou People's Hospital,Cangzhou 061002,Hebei,China;Department of Dermatology,Cangzhou People's Hospital,Cangzhou 061002,Hebei,China)
出处
《西部医学》
2025年第9期1386-1389,1395,共5页
Medical Journal of West China
基金
河北省2023年度医学科学研究课题(20231981)。
