摘要
Protein citrullination involves the deimination of arginine or methylarginine resi-dues in peptide chains to form citrulline by peptidyl arginine deiminases.This process is an important protein post-translational modification that affects molecular structure and func-tion of various proteins,including histones.In recent years,protein citrullination has attracted widespread attention for its influence on gene transcription.Studies on the impact of protein citrullination modification on chromatin structure remodeling and the establishment of gene regulatory networks have made rapid progress.In this review,we briefly summarize the phys-iological functions of protein citrullination modification.Specifically,we comprehensively outline the latest progress in the study of the role of protein citrullination modification in gene transcription regulation,focusing on the interaction of protein citrullination with other post-translational modifications.
基金
supported by the Tianjin Synthetic Biotech-nology Innovation Capacity Improvement Project(Grant No.TSBICIP-CXRC-048).
