摘要
Objective:To investigate the relationship between the composition of traditional Chinese medicine(TCM)and depression/anxiety/sleep disturbances(D/A/S)in patients with chronic pain.Methods:This cross-sectional study was conducted at 13 tertiary hospitals across China,enrolling patients who experienced chronic pain between November 2023 and May 2024.The Patient Health Questionnaire-9,Generalized Anxiety Disorder-7,Pittsburgh Sleep Quality Index,and TCM constitution categories were used to assess the patients.The association between the TCM constitution and the D/A/S ratio was analyzed using multivariable logistic regression.Results:A total of 1107 patients(63.2%women)were analyzed.Compared with those with a balanced constitution,patients who had qi-deficiency and yin-deficiency were at a higher risk of depression.Qideficiency and yin-deficiency were associated with anxiety.Sleep disturbances were common in patients with qi-deficiency constitution(odds ratio[OR]:2.32,95%confidence interval[CI]:1.42-3.81),yangdeficiency constitution(OR:1.94,95%CI:1.26-2.98),yin-deficiency constitution(OR:2.03,95%CI:1.24 -3.32),blood stasis constitution(OR:2.07,95%CI:1.01-4.22),and qi-stagnation constitution(OR:2.66,95%CI:1.35-5.25).Conclusion:In patients with chronic pain,specific TCM constitutions may be associated with D/A/S.Further longitudinal studies are needed to clarify the potential causal relationships between TCM constitution types and these conditions.
基金
supported by the Fundamental Research Funds for the Central Universities(2022-JYB-JBZR-035,2023-JYB-KYPT-11)
Qihuang Scholars Grant Project 2021.
