摘要
目的探讨青少年抑郁症患者动机性快感缺失的重复经颅磁刺激(rTMS)的临床疗效及安全性。方法选取2023年6月至2024年6月齐齐哈尔市精神卫生中心收治的80例青少年抑郁症患者作为研究对象,按照随机数字表法分为对照组和观察组,每组40例。两组均给予常规药物治疗,观察组给予rTMS治疗,对照组给予假刺激干预。比较两组患者的抑郁情绪严重程度、动机性快感缺失程度、治疗效果不良反应发生情况。结果干预后,观察组的抑郁自评量表(SDS)、汉密尔顿抑郁量表(HAMD)评分均低于对照组,差异有统计学意义(P<0.05)。干预后,观察组时间性快感体验量表(TEPS)中消费性快感体验、预期性快感体验评分均低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者的治疗相关不良反应总发生率比较,差异无统计学意义(P>0.05)。结论青少年抑郁症患者在抗抑郁药物治疗基础上加入rTMS进行联合治疗,可积极提升抗抑郁效果、减少动机性快感缺失,且治疗安全性良好。
Objective To investigate the clinical efficacy and safety of repetitive transcranial magnetic stimulation(rTMS)for motivational anhedonia in adolescents with depression.Methods A total of 80 adolescent depression patients admitted to Qiqihar Mental Health Centre from June 2023 to June 2024 were selected as the study subjects,and they were divided into the control group and the observation group according to the random number table method,with 40 cases in each group.Both groups received conventional drug therapy,with the observation group received rTMS treatment and the control group received sham stimulation intervention.The severity of depressive mood,the degree of motivational anhedonia,and the incidence of adverse effects of treatment were compared between the two groups.Results After the intervention,the scores of the self-depression scale(SDS)and Hamilton depression scale(HAMD)of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After the intervention,the scores of consummatory pleasure experience and anticipatory pleasure experience in the temporal experience of pleasure scale(TEPS)of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).During treatment,there was no significant difference in the total incidence of treatment-related adverse reactions between the two groups(P>0.05).Conclusion The addition of rTMS to antidepressant medication for the combined treatment of adolescent depressed patients positively enhances antidepressant effects,reduces motivational pleasure deficit,and has a favourable therapeutic safety profile.
作者
倪珂
万璐
回佳印
龙海雨
NI Ke;WAN Lu;HUI Jiayin;LONG Haiyu(Department of Sleep Psychological Rehabilitation,Qiqihar Mental Health Centre,Heilongjiang Province,Qiqihar161000,China)
出处
《中国当代医药》
2025年第23期62-66,共5页
China Modern Medicine
基金
黑龙江省卫生健康委科研课题(20230303090127)
黑龙江省齐齐哈尔市科技计划创新激励项目(CSFGG-2024134)。
关键词
青少年抑郁症
重复经颅磁刺激
动机性快感缺失
不良反应
Adolescent depression
Repeated transcranial magnetic stimulation
Motivational anhedonia
Adverse reaction
