摘要
目的探讨参松养心胶囊联合利伐沙班治疗气阴两虚型中高危心房颤动患者的临床疗效。方法选取2022年6月—2024年6月广东省第二中医院心血管科收治的气阴两虚型中高危心房颤动患者100例,按照随机信封、双盲法分为对照组与观察组各50例。对照组予以利伐沙班治疗,观察组另加用参松养心胶囊治疗。治疗3个月后评估2组临床疗效及不良反应发生率;比较2组治疗前后中医证候积分、炎性因子[白介素-6(IL-6)、高敏C反应蛋白(hs-CRP)]及胰岛素样生长因子(IGF-1)、促甲状腺激素(TSH)、P-选择素(GMP-140)水平。结果观察组总有效率为92.00%,高于对照组的84.00%(χ^(2)/P=6.859/<0.001);治疗3个月后,观察组中医证候积分低于对照组(t/P=5.378/0.001),观察组患者血清IL-6、hs-CRP水平低于对照组(t/P=9.444/<0.001、7.155/<0.001),观察组患者IGF-1、TSH、GMP-140水平低于对照组(t/P=5.602/<0.001、7.344/<0.001、9.029/<0.001);2组不良反应发生率比较差异无统计学意义(χ^(2)/P=0.211/0.646)。结论参松养心胶囊联合利伐沙班能有效控制气阴两虚型心房颤动患者症状,改善中医证候,降低炎性因子及脑卒中发生风险。
Objective To explore the clinical efficacy of Shensong Yangxin Capsule combined with rivaroxaban in the treatment of middle and high risk atrial fibrillation with deficiency of both qi and yin.Methods From June 2022 to June 2024,100 patients with moderate and high-risk atrial fibrillation of deficiency of both qi and yin were selected and divided into treatment group and control group according to random envelope and double-blind method,with 50 cases in each group.The control group was treated with rivaroxaban,while the treatment group was treated with Shensong Yangxin Capsule.The clinical efficacy and incidence of adverse reactions of the two groups were evaluated.The TCM syndrome score,inflammatory factors[Interleukin-6(IL-6),High-sensitivity C-reactive protein(hs-CRP)],Insulin-like growth factor(IGF-1),Thyroid stimulating hormone(TSH)and P-selectin(GPM-140)were compared between the two groups before and after treatment.Results The effective rate in the treatment group was significantly higher than that in the control group(χ^(2)/P=6.859/<0.001).After treatment,the scores of TCM syndromes,IL-6,hs-CRP,IGF-1,TSH and GMP-140 in the treatment group were lower than those in the control group(t/P=5.378/<0.001,9.444/<0.001,7.155/<0.001,5.602/<0.001,7.344/<0.001,9.029/<0.001).There was no significant difference in adverse reactions between the treatment group and the control group(P>0.05).Conclusion Shensong Yangxin Capsule combined with rivaroxaban can effectively control the symptoms of patients with atrial fibrillation of deficiency of both qi and yin,improve TCM syndromes,and reduce the risk of inflammatory factors and stroke.
作者
梁迪赛
包心仪
刘斯晗
袁丁
Liang Disai;Bao Xinyi;Liu Sihan;Yuan Ding(Department of Brain Diseases,Guangdong Second Traditional Chinese Medicine Hospital,Guangdong,Guangzhou 510095,China;不详)
出处
《疑难病杂志》
2025年第9期1036-1039,共4页
Chinese Journal of Difficult and Complicated Cases
基金
广东省医学会临床科研基金项目(A202301009)。
关键词
心房颤动
气阴两虚型
参松养心胶囊
利伐沙班
炎性因子
Atrial fibrillation
Deficiency of both qi and yin
Shensong Yangxin Capsule
Rivaroxaban
Inflammatory factor
