摘要
戊型肝炎(hepatitis E,HE)是一种由戊型肝炎病毒(hepatitis E virus,HEV)引起的急性病毒性肝炎,通常表现为自限性疾病。但近年来越来越多的证据表明,在部分免疫功能低下人群中HEV感染也可能发展成慢性感染,并最终导致重症肝炎、肝硬化和肝衰竭。在一些高危人群中,例如孕妇和器官移植者,HEV感染更是病死率极高,已经成为全球关注的公共卫生问题。因此,采用有效的诊断方法对HEV感染进行早期筛查、早期诊断与监测,对其预防、控制和治疗具有重大意义。本文概述了HEV的生物学特性,强调了当前人群感染HEV的高风险性,同时对HE的临床诊断指标、常用诊断策略以及预防和治疗方法进行了介绍,以期为我国降低乃至清除病毒性肝炎的目标提供新思路。
Hepatitis E(HE)is an acute viral hepatitis caused by hepatitis E virus(HEV),typically manifesting as a self-limiting disease.However,growing evidence in recent years suggests that HEV infection may progress to chronicity in certain immunocompromised individuals,ultimately leading to severe hepatitis,cirrhosis,and liver failure.Among high-risk groups,such as pregnant women and organ transplant recipients,HEV infection is associated with an alarmingly high mortality rate,emerging as a global public health concern.Therefore,adopting effective diagnostic methods for early screening,diagnosis,and monitoring of HEV infection is critical for HE prevention,control,and treatment.This paper summarizes the biological characteristics of HEV and highlights the current high-risk status of HEV infection in human populations.It also introduces the clinical diagnostic indicators,common diagnostic methods,as well as preventive and therapeutic approaches for HE.The review aims to offer new insights for achieving the goal of reducing and ultimately eliminating viral hepatitis in China.
作者
张鑫兰
艾湘君
刘如石
朱建蓉
万婷
胡锦莲
刘艳
ZHANG Xinlan;AI Xiangjun;LIU Rushi;ZHU Jianrong;WAN Ting;HU Jinlian;LIU Yan(School of Medical Technology and Translational Medicine,Hunan Normal University,Changsha 410013,Hunan,China;Hunan Xuxiang Biotechnology Co.,Ltd.,Changsha 410023,Hunan,China;School of Medicine,Jishou University,Jishou 416000,Hunan,China)
出处
《生命科学研究》
2025年第4期317-325,338,共10页
Life Science Research
基金
国家自然科学基金资助项目(31072141)
湖南省自然科学基金项目(12JJ2013)。
关键词
戊型肝炎病毒(HEV)
流行病学特征
诊断技术
预防策略
治疗进展
hepatitis E virus(HEV)
epidemiologic feature
diagnostic technique
prevention strategy
therapeutic advancement
