摘要
目的探讨超声药物透入治疗和封包疗法对中重度斑块型银屑病四肢肥厚性皮损的治疗效果。方法选取空军特色医学中心皮肤科2023年1月至2024年12月收治的中重度斑块型银屑病患者90例,按照随机数字表法分为封包组、超导组和对照组,每组30例。选取四肢肥厚性斑块状皮损作为试验部位。对照组采用常规治疗护理措施,包括口服抗组胺药物,静脉滴注抗过敏药物,外用糖皮质激素类药膏;封包组在对照组基础上对外用药物增施封包疗法;超导组在对照组基础上对外用药物增施超声药物透入治疗。以银屑病面积和严重度指数(psoriasis area and severity index,PASI)、斑块肥厚程度评分以及斑块消退时间作为评价指标,评估不同组别的治疗效果。结果PASI分值评估结果显示,3组患者接受治疗后,其PASI分值较治疗前均显著减少(P<0.001)。而治疗前及治疗后,3组患者PASI分值的组间差异均无统计学意义(P>0.05)。治疗后,四肢斑块肥厚程度评分结果显示,与封包组患者(0.96±0.61分)相比,超导组(0.43±0.50分)患者的皮损肥厚程度改善更为显著(P=0.001)。斑块消退时间的分析结果显示,超导组患者斑块消退时间(4.20±1.51 d)较封包组(5.46±2.20 d)(P<0.001)明显缩短。结论超声药物透入治疗改善四肢肥厚性斑块的程度和速度方面显著优于封包疗法,可有效缩短治疗时间。
Objective To explore the therapeutic effects of ultrasonic drug penetration therapy and occlusion therapy on hypertrophic lesions of extremities in moderate-to-severe plaque psoriasis.Methods A total of 90 patients with moderate-to-severe plaque psoriasis admitted to a tertiary hospital from January 2023 to December 2024 were selected and divided into the occlusion group,superconducting group,and control group,with 30 cases in each group.Hypertrophic plaque lesions on the extremities were selected as the test sites.The control group received conventional treatment and nursing measures,including oral antihistamines,intravenous infusion of anti-allergic drugs,and topical glucocorticoid ointments.The occlusive dressing group received occlusive dressing therapy in addition to topical medication as the control group.The ultrasound-mediated drug delivery group received ultrasound-mediated drug delivery therapy in addition to the same topical medication as the control group.Treatment efficacy was evaluated using the Psoriasis Area and Severity Index(PASI),plaque thickness scores,and plaque resolution time.Results PASI assessment showed that all three groups demonstrated significant reductions in PASI scores post-treatment compared to baseline(all P<0.001).No significant inter-group differences in PASI scores were observed either pre-treatment or post-treatment(all P>0.05).For limb plaque thickness scores post-treatment,the ultrasound-mediated drug delivery group(0.43±0.50 points)showed significantly greater improvement in plaque thickness compared to the occlusive dressing group(0.96±0.61 points)(P=0.001).Analysis of plaque resolution time revealed that the ultrasound-mediated drug delivery group(4.20±1.51 days)achieved significantly faster resolution than the occlusive dressing group(5.46±2.20 days)(P<0.001).Conclusion Ultrasound-mediated drug delivery therapy is significantly superior to occlusive dressing therapy in improving the degree and speed of hypertrophic plaque resolution in limbs,effectively shortening treatment duration.
作者
梁斌
张瑞桐
白明明
LIANG Bin;ZHANG Ruitong;BAI Mingming(Department of Dermatology,Air Force Characteristic Medical Center,Beijing 100142,China)
出处
《实用皮肤病学杂志》
2025年第4期274-278,共5页
Journal of Practical Dermatology
关键词
超声药物透入治疗
斑块型银屑病
经皮吸收
外用药
Ultrasound-mediated drug delivery therapy
Plaque psoriasis
Transdermal absorption
Topical medication[J Pract Dermatol,2025,18(4):274-278]
