摘要
目的分析洛阳市2015-2022年纳入治疗利福平耐药肺结核患者治疗转归情况及其影响因素,为耐药结核病防控工作提供参考。方法导出中国疾病预防控制信息系统子系统“监测报告管理”中2015-2022年洛阳市的耐药患者病案,对患者治疗结局的影响因素进行分析,单因素分析采用χ^(2)检验,多因素分析采用logistic回归法。结果2015-2022年洛阳市共纳入治疗511例利福平耐药肺结核患者,其中男389例(76.1%),女122例(23.9%),年龄(41.40±17.26)岁,成功治疗率为47.2%。单因素分析显示,不同性别、年龄、人群分类以及诊断和管理地区的成功治疗率差异有统计学意义(P<0.05)。多因素logistic回归分析表明,女性患者发生不良结局的风险比男性低49.9%(OR=0.501,95%CI:0.324~0.774);有固定工作患者发生不良结局风险比家务及待业者低49.2%(OR=0.508,95%CI:0.261~0.989);外地诊断和管理患者发生不良结局的风险是本地患者的2.394倍(OR=2.394,95%CI:1.385~4.137)。结论洛阳市利福平耐药肺结核患者的成功治疗率仍有待提高,治疗结局受性别、年龄、人群分类及诊断和管理地区等多因素影响。
Objective To analyze the treatment outcomes and influencing factors of rifampicin-resistant tuberculosis patients in Luoyang from 2015 to 2022,providing references for the prevention and control of rifampicin-resistant tuberculosis.Methods The cases of rifampicin-resistant patients in Luoyang from 2015 to 2022 were extracted from the“surveillance report management”subsystem of the China disease prevention and control information system.Factors influencing the treatment outcomes of patients were analyzed.Univariate analysis was conducted using theχ^(2)test,and multivariate analysis was performed using logistic regression.Results A total of 511 rifampicin-resistant tuberculosis patients were included from 2015 to 2022,comprising 389 males(76.1%)and 122 females(23.9%),with an age of(41.40±17.26)years.The successful treatment rate was 47.2%.Univariate analysis showed that the success rate of treatment varied significantly by gender,age group,population classification,and diagnosis and management regions(P<0.05).Multivariate logistic regression analysis indicated that female patients had a 49.9%lower risk of adverse outcomes compared to males(OR=0.501,95%CI:0.324-0.774),patients with stable employment had a 49.2%lower risk of adverse outcomes compared to those engaged in domestic duties or unemployed(OR=0.508,95%CI:0.261-0.989),patients diagnosed and managed from other areas had a 2.394 times higher risk of adverse outcomes compared to local patients(OR=2.394,95%CI:1.385-4.137).Conclusion The successful treatment rate of rifampicin-resistant tuberculosis patients in Luoyang needs improvement.Treatment outcomes are influenced by factors such as gender,age,population classification,and the regions of diagnosis and management.
作者
陈淑贤
徐雅斐
郭美芳
陈书文
CHEN Shuxian;XU Yafei;GUO Meifang;CHEN Shuwen(Tuberculosis Prevention and Control Institute,Luoyang Center for Disease Control and Prevention,Luoyang 471000,China;School of Public Health,Shanxi Medical University,Taiyuan 030001,China)
出处
《河南医学研究》
2025年第17期3073-3077,共5页
Henan Medical Research
关键词
利福平耐药肺结核
治疗结局
影响因素
rifampicin-resistant tuberculosis
treatment outcome
influencing factor
