摘要
马尔尼菲篮状菌是一种罕见的机会性致病菌,马尔尼菲篮状菌感染具有起病隐匿、临床表现不典型、早期确诊率低、误诊率及病死率高等特点,近年受到了广泛的关注。器官移植受者因术后免疫抑制治疗成为马尔尼菲篮状菌感染的高危人群。通过宏基因组二代测序、靶向抗真菌治疗及免疫抑制方案调整等措施是改善器官移植术后马尔尼菲篮状菌感染患者预后的关键。本文就马尔尼菲篮状菌感染在器官移植受者中的流行病学特征、致病机制、诊断方法及治疗策略进行综述,并探讨了当前面临的挑战及未来研究方向,以期为器官移植受者马尔尼菲篮状菌感染的诊疗提供参考。
Talaromyces marneffei is a rare opportunistic pathogen.Talaromyces marneffei infection is characterized by insidious onset,atypical clinical manifestations,low early diagnosis rate,and high misdiagnosis and fatality,and has received widespread attention in recent years.Organ transplant recipients become a high-risk group for Talaromyces marneffei infection due to postoperative immunosuppressive therapy.Metagenomic next-generation sequencing,targeted antifungal therapy,and immunosuppression regimen adjustment are key to improving the prognosis of Talaromyces marneffei infection patients.This article reviews the epidemiology,pathogenesis,diagnosis and treatment of Talaromyces marneffei infection in organ transplant recipients,explores current challenges and future research directions,and aims to inform the diagnosis and treatment of Talaromyces marneffei infection.
作者
李善达
陈羽翔
施浩然
马晓杰
李涛
蒋鸿涛
Li Shanda;Chen Yuxiang;Shi Haoran;Ma Xiaojie;Li Tao;Jiang Hongtao(Department of Kidney Transplantation,the Second Affiliated Hospital of Hainan Medical University,Haikou 570100,China;不详)
出处
《器官移植》
北大核心
2025年第5期805-811,共7页
Organ Transplantation
基金
国家重点研发计划(2024YFC3406800)
国家自然科学基金(82460153、82400891)
海南省卫生健康科技创新联合项目(WSJK2025MS163)
海南省研究生创新科研课题(Qhys2024-467、Qhyb2023-179)。
关键词
器官移植
马尔尼菲篮状菌
真菌感染
侵袭性
宏基因组二代测序
免疫抑制
巨噬细胞
Organ transplantation
Talaromyces marneffei
Fungal infection
Invasive
Metagenomic nextgeneration sequencing
Immunosuppression
Macrophage
Amphotericin B
