摘要
2015年国际腹水俱乐部就肝肾综合征的进展提出了肝肾综合征-急性肾损伤的新定义,目前其确切发病机制仍在探索中。肠道屏障在肝肾连接中发挥重要桥梁作用,肠道菌群紊乱,细菌易位发生,内毒素入血,通过释放促炎细胞因子、激活免疫相关细胞对肾脏造成损害,胆汁酸进入循环系统也直接或间接导致肝肾综合征-急性肾损伤的发生与进展。本文以肠道屏障为切入点对肝肾综合征-急性肾损伤的串扰机制进行综述,进一步阐明肝-肠-肾轴在其发病中的关键作用,以期提供新的治疗思路。
In 2015,the International Ascites Club proposed a new definition of hepatorenal syndrome-acute kidney injury based on the progression of hepatorenal syndrome,and studies are still being conducted to explore the exact pathogenesis of hepatorenal syndrome-acute kidney injury.Intestinal barrier plays an important bridging role in liver-kidney connection,and intestinal flora disturbance,bacterial translocation,and endotoxins entering the blood cause damage to the kidneys by releasing proinflammatory cytokines and activating immune-related cells.The entrance of bile acid into the circulation system also directly or indirectly lead to the development and progression of hepatorenal syndrome-acute kidney injury.This article reviews the crosstalk mechanism of hepatorenal syndrome-acute kidney injury from the perspective of the intestinal barrier and further clarifies the key role of the liver-gut-kidney axis in the pathogenesis of this disease,in order to provide new treatment ideas.
作者
孙文
陈晓
张鑫
于博睿
杨波
邢海涛
SUN Wen;CHEN Xiao;ZHANG Xin;YU Borui;YANG Bo;XING Haitao(Department of Nephrology,The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300193,China)
出处
《临床肝胆病杂志》
北大核心
2025年第8期1685-1692,共8页
Journal of Clinical Hepatology
基金
国家自然科学基金(81973799)
天津市教委科研计划(2023KJ154)。
关键词
肠道屏障
肝硬化
肝肾综合征
急性肾损伤
细菌易位
Intestinal Barrier
Liver Cirrhosis
Hepatorenal Syndrome
Acute Kidney Injury
Bacterial Translocation
