摘要
脓毒症相关脑病(SAE)是重症患者常见的并发症,其病理机制复杂且缺乏特异性治疗。近年研究发现,肠道菌群通过“肠-脑轴”调控神经炎症与血脑屏障(BBB)功能,成为SAE干预的新方向。本文综述肠道菌群失调在SAE中的作用机制,探讨益生菌、粪菌移植、靶向菌群代谢产物及信号通路的治疗策略,未来的研究需结合多组学技术与临床转化验证。
Sepsis-associated encephalopathy(SAE)is a common complication in critically ill patients,and its pathogenesis is complex and lacks specific treatment.In recent years,gut flora has been found to regulate neuroinflammation and blood-brain barrier function through the“gut-brain axis”,which has become a new direction for SAE intervention.In this paper,we review the role of gut dysbiosis in SAE,explore the therapeutic strategies of probiotics,fecal transplants,and targeting of bacterial metabolites and signaling pathways,and future research should integrate multi-omics techniques with clinical translational validation.
作者
尚伟锋
陈德昌
Shang Weifeng;Chen Dechang(Department of Critical Care Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《中华重症医学电子杂志》
2025年第1期31-35,共5页
Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)
基金
国家自然科学基金项目(82241044,82172152)
关键词
肠道菌群
肠道代谢产物
脓毒症相关脑病
治疗靶点
Gut microbiota
Gut metabolites
Sepsis-associated encephalopathy
Therapeutic targets
