摘要
When mammals are exposed to cold,their metabolism undergoes substantial changes.The liver plays a central role in maintaining energy homeostasis by shifting from glucose metabolism to lipid catabolism.A recent study by Davidson et al.^([1]),published in Cell Metabolism,highlights a novel mechanism involving lysosomal lipid remodeling during cold adaptation.Specifically,the study reveals that cold exposure elevates hepatic levels of Bis(Monoacylglycerol)Phosphate(BMP)lipids,which are regulated by Transcription Factor EB(TFEB)and Phospholipase A2 group XV(PLA2G15).
