摘要
颅内动脉瘤(intracranial aneurysm,IA)是一种颅内血管的异常瘤样突起,具有较高的发病率,一旦破裂可导致明显的不良预后。糖尿病(diabetes mellitus,DM)是一种常见的慢性疾病,以血糖水平长期升高为特征,给患者身体健康带来不良影响。既往长期高血糖水平会影响血管健康已被广泛证实,而脆弱的血管是动脉瘤发生的重要前提,基于此,糖尿病患者动脉瘤发生率可能较非糖尿病患者更高。然而,亦有部分研究结果与此存在矛盾。明确糖尿病在颅内动脉瘤形成及破裂后导致蛛网膜下腔出血等方面的机制研究有利于糖尿病患者在发现颅内动脉瘤后合理进行个体化治疗,改善预后。本文就糖尿病对颅内动脉瘤形成、破裂的影响及相关危险因素作一综述。
Intracranial aneurysm(IA)is an abnormal tumor-like protrusion of intracranial blood vessels and has a relatively high in-cidence rate,and its rupture can lead to significantly poor prognosis.Diabetes mellitus(DM)is a common chronic disease character-ized by prolonged elevation of blood glucose level,which adversely affects the health of patients.Studies have confirmed the impact of long-term hyperglycemia on vascular health,and fragile blood vessels are an important prerequisite for the onset of aneurysms.There-fore,the patients with DM may have a higher incidence rate of aneurysms than those without DM.However,some studies have yielded conflicting results.Clarifying the mechanisms by which DM promotes the formation of IA and leads to subarachnoid hemorrhage after rupture may help to provide rational and individualized treatment for DM patients upon the identification of aneurysms and improve their prognosis.This article reviews the impact of DM on the formation and rupture of IA and related risk factors.
作者
谭茂露
张可
吕发金
Tan Maou;Zhang Ke;LüFajin(Department of Radiology,The First Affiliated Hospital of Chongqing Medical University)
出处
《重庆医科大学学报》
北大核心
2025年第8期1005-1010,共6页
Journal of Chongqing Medical University
基金
国家重点研发计划资助项目(编号:2020YFA07104002)
重庆健康适宜技术促进资助项目(编号:2023jstg044)
重庆科技局技术创新与应用开发重点资助项目(编号:CSTC2021jscx-ksbN0030)
重庆健康委员会和科技局联合资助项目(编号:2022ZDXM006)。
关键词
颅内动脉瘤
糖尿病
发病机制
相关性
综述
intracranial aneurysm
diabetes mellitus
pathogenesis
association
review
