摘要
目的评估非常早产儿出生后第2周的甲状腺功能,分析甲状腺功能异常的影响因素。方法回顾性分析128例非常早产儿的临床资料,根据出生后第2周甲状腺功能检查结果分为正常组(115例)和异常组(13例)。分析非常早产儿的临床特征,并对非常早产儿发生甲状腺功能异常的影响因素进行单因素及多因素Logistic回归分析。结果本研究共纳入新生儿128例,男71例(55.5%),胎龄30.1(29.0,31.0)周,出生体重1400(1250,1575)g,住院时间49.5(38.0,64.5)d,13例(10.2%)甲状腺功能异常,均为孤立性高促甲状腺激素(TSH)血症。与正常组的30.3(29.1,31.0)周、(1446±275)g、4.3%相比,异常组胎龄29.1(28.6,29.7)周、出生体重(1115±286)g更小,小于胎龄儿占比23.1%更大,差别具有统计学意义(P<0.05)。两组的男性、双胎妊娠、产前激素、应用表面活性物质、机械通气、动脉导管未闭、新生儿坏死性小肠结肠炎(NEC)、颅内出血占比及住院时间比较,差别不具有统计学意义(P>0.05)。以甲状腺功能检测结果为因变量(正常=0,异常=1),以单因素分析中有统计学差异的指标为自变量(胎龄、出生体重和小于胎龄儿)进行多因素Logistic回归分析显示,低出生体重是非常早产儿甲状腺功能异常的独立危险因素[OR=1.004,95%CI=(1.000,1.008),P=0.037<0.05]。结论低出生体重非常早产儿的甲状腺功能异常风险更高,出生后第2周完善甲状腺功能检查有助于早期识别甲状腺功能异常。
Objective To assess the thyroid function of very preterm infants in the 2nd week after birth and to analyze the influencing factors of abnormal thyroid function.Methods The clinical data of 128 cases of very preterm infants were retrospectively analyzed and divided into normal group(115 cases)and abnormal group(13 cases)according to the results of thyroid function examination in the 2nd week after birth.The clinical characteristics of very premature infants were analyzed,and univariate and multivariate Logistic regression analyses were conducted on the influencing factors of abnormal thyroid function in very premature infants.Results A total of 128 newborns were included in this study,including 71 males(55.5%),with a gestational age of 30.1(29.0,31.0)weeks,a birth weight of 1400(1250,1575)g,a hospitalization time of 49.5(38.0,64.5)d,and 13 cases(10.2%)had abnormal thyroid function,all of which were isolated hyperthyrotropinemia.Compared with the normal group[30.3(29.1,31.0)weeks,(1446±275)g and 4.3%],the abnormal group had a smaller gestational age 29.1(28.6,29.7)and birth weight(1115±286)g,and a higher proportion of small-for-gestationalage infants(23.1%).The differences were statistically significant(P<0.05).There were no statistically significant differences between the two groups in terms of proportions of male,twin pregnancy,prenatal hormones,use of surfactant,mechanical ventilation,patent ductus arteriosus,neonatal necrotizing enterocolitis(NEC),intracranial hemorrhage,and hospitalization time(P>0.05).Multivariate Logistic regression analysis was conducted with the results of thyroid function tests as the dependent variable(normal=0,abnormal=1),and the indicators with statistical differences in the univariate analysis(gestational age,birth weight,and small-for-gestational-age infants)as independent variables.The results showed that low birth weight was an independent risk factor for thyroid dysfunction in very preterm infants[OR=1.004,95%CI=(1.000,1.008),P=0.037<0.05].Conclusion Very preterm infants with lower birth weight are at higher risk of abnormal thyroid function,and refinement of thyroid function tests in the 2nd week after birth can help in early recognition of abnormal thyroid function.
作者
洪艺珠
许凤妹
郑真真
HONG Yi-zhu;XU Feng-mei;ZHENG Zhen-zhen(Quanzhou Maternity and Children's Hospital(Quanzhou Children's Hospital),Quanzhou 362000,China)
出处
《中国现代药物应用》
2025年第20期28-31,共4页
Chinese Journal of Modern Drug Application
关键词
新生儿
甲状腺功能
非常早产儿
出生体重
早期识别
Neonate
Thyroid function
Very preterm infants
Birth weight
Early identification
