摘要
酸枣仁为鼠李科植物酸枣Ziziphus jujuba Mill.var.spinosa(Bunge)Hu ex H.F.Chou的干燥成熟种子,具有养心补肝、宁心安神、敛汗生津的功效,在中医中被广泛用于治疗失眠。酸枣仁中的主要活性成分集中在皂苷类、黄酮类、生物碱类、脂肪酸类等物质,如酸枣仁皂苷A、酸枣仁皂苷B、斯皮诺素、白桦脂酸等,均具有抗失眠作用。现代药理学研究表明,酸枣仁及其活性成分可能通过调节肠道菌群、下丘脑-垂体-肾上腺轴、神经递质、炎性因子等作用机制发挥抗失眠作用。本文通过检索近年来国内外相关文献,对酸枣仁抗失眠活性成分进行筛选,综述了酸枣仁抗失眠活性成分及其抗失眠作用机制,以期为抗失眠药物的开发提供参考,助力中医药在失眠领域的广泛应用。
Ziziphi Spinosae Semen,the dried mature seeds of Ziziphus jujuba Mill.var.spinosa(Bunge)Hu ex H.F.Chou,rich in nutrients with health benefits,including nourishing the heart and the liver,calming the mind,and promoting sweat gland function.They are widely used for insomnia.The main active ingredients in jujube seeds included saponins,flavonoids,alkaloids,and fatty acids,such as jujuboside A,jujuboside B,spinosin,and betulinic acid,which all have anti-insomnia effects.Modern pharmacological studies suggest that Ziziphi Spinosae Semen and their active ingredients may exert their anti-insomnia effects through regulating the gut microbiome,the hypothalamus-pituitary-adrenal axis,neurotransmitter levels,and inflammatory factors.This article reviewed the anti-insomnia active ingredients and mechanism of Ziziphi Spinosae Semen by searching recent literature at home and abroad,providing reference for the development of anti-insomnia drugs and promoting the widespread use of traditional Chinese medicine for insomnia.
作者
井泽
李先娜
杨波
JING Ze;LI Xian-na;YANG Bo(Heilongjiang University of Chinese Medicine,Harbin 150040)
出处
《中南药学》
2025年第8期2388-2394,共7页
Central South Pharmacy
基金
中国博士后科学基金第17批特别资助(No.2024T170257)
黑龙江省自然科学基金面上项目(No.D200846)
黑龙江省自然科学基金联合引导项目(No.LH2023H069)。
关键词
酸枣仁
失眠
活性成分
作用机制
Ziziphi Spinosae Semen
insomnia
active ingredient
mechanism of action
