摘要
食管癌是全球范围内发病率高且预后较差的消化道恶性肿瘤,其中约40%的病例集中在中国,5年生存率不足20%。传统影像学方法在精准诊疗中存在明显的局限性,而PET/CT影像组学通过高通量提取并分析肿瘤的形态学、代谢及纹理特征,为食管癌的精准分期、治疗反应动态监测及个体化预后预测提供了新视角。文章系统综述了^(18)F-FDG PET/CT影像组学在食管癌诊疗中的研究进展,探讨其与基因组学、剂量组学等的交叉融合潜力,并对未来发展方向进行了展望,以期为临床转化提供更全面的理论支持。
Esophageal cancer is a gastrointestinal malignancy with a high incidence and poor prognosis worldwide,with about 40%of cases concentrated in China,and the 5-year survival rate is less than 20%.Traditional imaging methods exhibit significant limitations in precision diagnosis and treatment.In contrast,PET/CT radiomics-through high-throughput extraction and analysis of tumor morphological,metabolic,and textural features-provides a novel perspective for accurate staging,dynamic therapeutic response monitoring,and individualized prognosis prediction in esophageal cancer.This article systematically reviews the research progress of ^(18)F-FDG PET/CT radiomics in the diagnosis and treatment of esophageal cancer,discusses its potential-integration with genomics and dosiomics,and looks forward to the future development direction,in order to provide more comprehensive theoretical support for clinical translation.
作者
王宣彦
顾莹莹
唐立钧
李天女
WANG Xuanyan;GU Yingying;TANG Lijun;LI Tiannü(Department of Nuclear Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《南京医科大学学报(自然科学版)》
北大核心
2025年第9期1251-1257,共7页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家卫生健康委核医学重点实验室
江苏省分子核医学重点实验室(KF202206)。
