摘要
CONSPECTUS:In addition to supporting and protecting mobility,bone is essential for regulating systemic homeostasis.Large bone defects have always been a clinical challenge because of their complicated composition and structure,which makes them difficult to repair on their own.Currently,clinical operations employ primarily autologous,allogeneic,and synthetic bone grafting methods,which are still limited by factors such as donor scarcity,complications from infections,and market acceptance.Thus,novel biomimetic artificial bone tissue engineering scaffolds can be created by designing and regulating the composition and structure of materials,drawing inspiration from the intrinsic properties of genuine bone tissue.
基金
supported by the National Natural Science Foundation(82471033,82272493)
the Haidian Frontier Project of Beijing Natural Science Foundation(L222092,L212066)
the Independent Scientific Research Projects of the Laboratory(2023-JSKY-SSOG-007)
the Project of Science and Technology Department of Jilin Province(20230505030ZP).
