摘要
慢性应激触发肿瘤免疫微环境失稳态是推动肺癌发生的关键因素。基于中医“神”与慢性应激及“气”与“免疫”之间的映射关系,认为“慢性应激-TIME-肺癌”交联机制与中医“形气神同病”的病机表征关联,“神”“气”紊乱是推动肺癌“形”变的根本,亦是防治“形”变之关键。根据协同改善慢性应激之“调神”及重塑TIME之“助气”的治疗原则,把握肺癌演进各阶段的核心病机以谴方施药,充分借鉴临床经验及药理学研究成果以精准打靶,联合针灸、功法、音疗等特色疗法共同调复神经-内分泌-免疫网络稳态以治“形”,以期为肺癌的综合防治体系提供新思路与可及性方案。
Chronic stress triggers the imbalance of the homeostasis of the tumor immune microenvironment(TIME),which is a key factor driving the development of lung cancer.Based on the mapping relationship between the concept of"spirit"in traditional Chinese medicine and chronic stress,and between"qi"and"immunity",it is believed that the cross-linking mechanism of"chronic stress-TIME-lung cancer"aligns with the understanding of traditional Chinese medicine of disease as involving the interplay between the"body,qi and spirit".The disorganization of"spirit"and"qi"is not only the root of the change of the"form",but also the key to prevent and control it.The treatment principle of synergizing to improve the chronic stress of"regulating the spirit"and remodeling the TIME of"invigorating the qi"is further proposed,which emphasizes on grasping the core pathogenesis of lung cancer at each stage of its evolution in order to administer medicines,drawing on the clinical experience and pharmacological research results in order to accurately hit the target,and combining special therapies like acupuncture,Chinese kungfu,sound therapy to treat the change of"shape"by modulating neuro-endocrine-immune network homeostasis,so as to provide new ideas and accessible solutions for the comprehensive prevention and treatment system of lung cancer.
作者
文进渝
何佳玮
郑川
钟杨
姜玉玲
付西
由凤鸣
马琼
WEN Jinyu;HE Jiawei;ZHENG Chuan;ZHONG Yang;JIANG Yuling;FU Xi;YOU Fengming;MA Qiong(Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Cancer Research Institute,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《世界科学技术-中医药现代化》
北大核心
2025年第8期2244-2253,共10页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委青年科学基金项目(82405359):“调神助气”重塑肺癌免疫微环境:以开心散改善精神压力调控Kisspeptin/GPR54轴逆转CD8+T细胞耗竭为例,负责人:付西
四川省科技厅自然科学基金项目(2024NSFSC1868):基于“MCT4-乳酸”轴介导TAMs极化失衡探讨川结方重塑肺癌免疫微环境的作用机制,负责人:付西
四川省中医药管理局科学技术研究专项(2023ZD06):基于肺结节/早期肺癌类器官的中医药研究创新团队,负责人:由凤鸣。
关键词
肺癌
肿瘤免疫微环境
调神助气
慢性应激
Lung cancer
Tumor immune microenvironment
Regulating spirit and invigorating qi
Chronic stress
