摘要
目的研究在不同指南推荐甘油三酯水平下残余胆固醇(remnant cholesterol,RC)与代谢相关脂肪性肝病(metabolic-associated fatty liver disease,MAFLD)发病风险的关系。方法研究数据来源于2023年某社区体检的65岁及以上的老年人数据。使用回归分析评估整体人群RC与MAFLD风险的关系。依据中国血脂管理指南推荐的甘油三酯合适水平(<1.7 mmol/L)及欧洲动脉粥样硬化学会提出的甘油三酯理想目标(<1.2 mmol/L),将人群划分为不同甘油三酯水平的亚组,研究不同甘油三酯水平分层中RC与MAFLD风险的关联度。结果本次研究共纳入2800名年龄在65岁及以上老年人。MAFLD发病率为20.85%。RC是MAFLD风险的独立影响因子(P<0.001)。在甘油三酯<1.7 mmol/L的老年个体中,RC水平与MAFLD发病风险相关性不显著(P=0.888);在甘油三酯≥1.7 mmol/L的老年个体中,RC水平与MAFLD发病风险显著正相关(P<0.001);交互检验显示分层因素对RC的效应量无显著交互作用(P=0.115)。在甘油三酯<1.2 mmol/L的老年个体中,RC水平与MAFLD发病风险不相关(P=0.505);而甘油三酯≥1.2 mmol/L的老年个体中,RC水平与MAFLD发病风险显著相关(P<0.001);交互检验显示分层因素对RC的效应量有显著交互作用(P=0.011)。结论RC是老年MAFLD风险的独立影响因子。为降低老年人RC相关的MAFLD风险,甘油三酯<1.2 mmol/L可作为识别早期风险的参考依据。
Objective This study aims to investigate the association between remnant cholesterol(RC)and the risk of metabolic-associated fatty liver disease(MAFLD)under the optimal triglyceride(TG)levels recom-mended by different guidelines.Methods The data were derived from the annual physical examinations of elderly people aged 65 and above in a community in 2023.Regression analysis was used to evaluate the association between RC and MAFLD risk.According to the TG normal level(<1.7 mmol/L)recommended by the Chinese Lipid Management Consensus and the TG ideal target(<1.2 mmol/L)proposed by the European Atherosclerosis Society,the individuals were divided into subgroups with different TG levels to explore the association between RC and MAFLD risk in each subgroup.Results A total of 2,800 elderly individuals aged 65 and above were included in this study.The proportion of the individuals meeting the diagnostic criteria for MAFLD was 20.85%,and RC was identified as an independent risk factor for MAFLD(P<0.001).In the elderly individuals with TG<1.7 mmol/L,RC level was not significantly associated with MAFLD risk(P=0.888).In contrast,in the elderly individuals with TG≥1.7 mmol/L,RC level was significantly and positively correlated with MAFLD risk(P<0.001).Interaction tests revealed no significant interaction between the stratification factor and the effect size of RC(P=0.115).In the elderly individuals with TG<1.2 mmol/L,RC level was not associated with MAFLD risk(P=0.505),while in the elderly individuals with TG≥1.2 mmol/L,RC level was significantly associated with MAFLD risk(P<0.001).Interaction tests showed a significant interaction between the stratification factor and the effect size of RC(P=0.011).Conclusion RC is an independent risk factor for MAFLD in older individuals.To reduce the risk of MAFLD related to RC in the elderly,a triglyceride level of<1.2 mmol/L can serve as a reference for identifying early-stage risk.
作者
苏丽丽
李诺
方卫
陈蒙华
覃斯娜
杨叶桂
SU Lili;LI Nuo;FANG Wei;CHEN Menghua;QIN Sina;YANG Yegui(Department of Ultrasound Medicine,First Affiliated Hospital of Guilin Medical University,Guilin 541000,Guangxi,China;不详)
出处
《实用医学杂志》
北大核心
2025年第17期2676-2682,共7页
The Journal of Practical Medicine
基金
国家自然科学基金项目(编号:82072128)
广西科技计划项目(编号:桂科AB22080088)
广西壮族自治区自筹科研项目(编号:Z-A20230678,Z-A20220659)。
关键词
代谢相关脂肪性肝病
甘油三酯
残余胆固醇
交互作用
metabolic-associated fatty liver disease
remnant cholesterol
triglyceride
interaction effect
