摘要
目的研究热敏灸联合黄芪多糖用于晚期卵巢癌化疗患者中的临床价值。方法选取2018年6月至2022年10月九江市第一人民医院收治的60例晚期卵巢癌化疗患者作为研究对象,按照随机列表法分为联合组和对照组,每组30例。联合组给予热敏灸联合黄芪多糖治疗,对照组给予黄芪多糖治疗。比较两组治疗总有效率,治疗前后中医证候积分、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+))、糖类抗原(carbohydrate antigen,CA)125、癌胚抗原(carcinoembryonic antigen,CEA)、CA19-9及不良反应发生情况。结果联合组治疗总有效率为86.67%,高于对照组的63.33%,差异有统计学意义(P<0.05)。治疗后,两组小腹坠胀疼痛、面色萎黄、畏寒肢冷、经色紫黯积分均低于治疗前,且联合组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组CD3^(+)、CD4^(+)水平均高于治疗前,CD8^(+)水平均低于治疗前,且联合组CD3^(+)、CD4^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组CA125、CEA、CA19-9水平均低于治疗前,且联合组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论热敏灸联合黄芪多糖用于晚期卵巢癌化疗患者的治疗效果更为理想,可快速减轻患者症状,改善其免疫功能,降低肿瘤标志物水平,且患者不良反应少,值得临床推广应用。
Objective To study the clinical value of heat-sensitive moxibustion combined with astragalus polysaccharide in patients with advanced ovarian cancer chemotherapy.Methods 60 patients with advanced ovarian cancer chemotherapy included in Jiujiang NO.1 People's Hospital from June 2018 to October 2022 were selected as the study subjects,and they were divided into the combined group and the control group according to the random list method,with 30 cases in each group.The combined group adopted heat-sensitive moxibustion combined with astragalus polysaccharide,and the control group adopted Astragalus polysaccharide.The total effective rate of treatment,the Traditional Chinese Medicine(TCM)syndrome scores,T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+)),carbohydrate antigen(CA)125,carcinoembryonic antigen(CEA)and CA19-9 before and after treatment,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the combined group was 86.67%,which was higher than 63.33%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of abdominal distension and pain,sallow complexion,aversion to cold and cold limbs,and dark purple menstrual blood of the two groups were lower than those before the treatment,and the combined group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of CD3^(+)and CD4^(+)of the two groups were higher than those before treatment,while the level of CD8^(+)was lower than that before treatment,and the levels of CD3^(+)and CD4^(+)in the combined group were higher than those in the control group,and the level of CD8^(+)was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CA125,CEA and CA19-9 of the two groups were lower than those before the treatment,and the combined group was lower than the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion The effect of heat-sensitive moxibustion combined with astragalus polysaccharide is more ideal,which can quickly reduce the symptoms of patients,improve their immune capacity,and reduce the level of tumor markers,less adverse reactions of patients,which is worth of clinical promotion and application.
作者
徐秀兰
石玲
梅耀国
刘智
XU Xiulan;SHI Ling;MEI Yaoguo;LIU Zhi(Department of Gynecology,Jiujiang NO.1 People's Hospital,Jiujiang,Jiangxi,332000,China;Department of Oncology,Jiujiang NO.1 People's Hospital,Jiujiang,Jiangxi,332000,China;Department of Oncology,Jiujiang Hospital of Traditional Chinese Medicine,Jiujiang,Jiangxi,332000,China;Department of Anorectal,Lianxi District Hospital of Traditional Chinese Medicine of Jiujiang,Jiujiang,Jiangxi,332000,China)
出处
《当代医学》
2025年第5期17-21,共5页
Contemporary Medicine
基金
江西省中医药管理局科技计划(2023B1036)。
关键词
晚期卵巢癌
热敏灸
化疗
黄芪多糖
免疫功能
Advanced ovarian cancer
Heat-sensitive moxibustion
Chemotherapy
Astragalus polysaccharide
Immune function
