摘要
Objective:This research examined the effects of extracts(alkaloid and phenolic)from the leaves of Senna occidentalis on the oxidative status of heart in Wistar rats fed high-fat diets and induced with streptozotocin.Type 2 diabetes was established in the rats by injecting 35 mg/kg of streptozotocin intraperitoneally.Materials and Methods:Forty-three experimental rats were randomly categorized into seven groups of six rats each,with Group 1 as control group,which comprised seven rats.The remaining groups were as follows:group 2(untreated diabetic rats),Group 3(metformin-treated diabetic rats),Group 4(phenolic extract-treated diabetic rats),Group 5(alkaloids extract-treated diabetic rats),Group 6(high-dose phenolic extract-treated diabetic rats),and Group 7(high-dose alkaloids extract-treated diabetic rats).Results:The activity levels of various biochemical factors such as catalase,superoxide dismutase,glutathione-S-transferase,glutathione peroxidase,glutathione,and malondialdehyde were assessed to determine antioxidant status.Conclusions:The findings of this study demonstrated that the phenolic and alkaloid extracts from S.occidentalis possess antioxidant properties and show promise in the management of type 2 diabetes.
