摘要
目的 探讨分析碳酸锂治疗药物监测(TDM)结果,为碳酸锂药物的合理使用提供参考。方法 收集2023年1~12月在我院门诊进行碳酸锂血药浓度监测患者的年龄、性别和监测频次等,运用SPSS 26.0统计学软件对数据进行分析。结果 男性患者监测137次(35.68%),女性监测247次(64.32%),监测频次为1次的占比高达63.4%,血药浓度达标率为45.05%;在多重线性回归方程中,性别、年龄、给药剂量仅能对8.2%的血药浓度变化作出解释。女性患者的血药物浓度/剂量比(C/D)略低于男性,但差异无统计学意义(P>0.05)。>59岁患者的C/D值高于18~59岁、<18岁患者,差异有统计学意义(P<0.05)。结论 在临床用药过程中,应为患者建立个体化给药方案,以提高碳酸锂血药浓度的达标率,同时应提高门诊患者碳酸锂TDM的重视程度,建议定期监测碳酸锂药物的血药浓度,进而提升临床用药的安全性与疗效。
Objective To explore and analyze the results of therapeutic drug monitoring(TDM)of lithium carbonate blood concentration,and to provide a reference for the rational use of lithium carbonate.Methods Data on age,gender,and TDM frequency were collected from outpatients who underwent lithium carbonate blood concentration monitoring in our hospital from Jan to Dec 2023.Statistical analysis was performed using SPSS 26.0 software.Results Male patients were monitored 137 times(35.68%)and female patients 247 times(64.32%).The proportion of patients with only one monitoring session was as high as 63.4%,and the attainment rate of blood drug concentration was 45.05%.Multiple linear regression analysis showed that gender,age,and administered dose explained only 8.2%of the variation in blood concentration.The concentration/dose ratio(C/D)of female patients was slightly lower than that of male patients,with no statistically significant difference(P>0.05).The C/D of patients over 59 years old was higher than that of patients aged 18~59 and under 18,with a statistically significant difference(P<0.05).Conclusion In clinical practice,individualized dosing regimens should be established for patients to improve the compliance rate of lithium carbonate blood concentration.Meanwhile,attention to TDM of lithium carbonate in outpatients should be strengthened,and regular monitoring of lithium carbonate blood concentration is recommended to enhance the safety and efficacy of clinical medication.
作者
梅丽平
王亚军
张春杰
于杰
白福臣
Mei Liping;Wang Yajun;Zhang Chunjie;Yu Jie;Bai Fuchen(Department of Laboratory,Chifeng City Anding Hospital,Chifeng 024000)
出处
《中国现代医药杂志》
2025年第8期16-19,共4页
Modern Medicine Journal of China
基金
赤峰市自然科学科研课题项目(编号:SZR2023129)。
关键词
碳酸锂
治疗药物监测
血药浓度
浓度剂量比值
影响因素
Lithium carbonate
Therapeutic drug monitoring(TDM)
Blood drug concentration
Concentration
dose ratio(C
D)
Influencing factors
