摘要
慢性乙型肝炎病毒(hepatitis B virus,HBV)感染会导致一系列肝脏相关疾病,严重威胁身体健康。HBV的持续性感染和慢性化过程与肝细胞核内存在的共价闭合环状DNA(covalently closed circular DNA,cccDNA)密切相关。HBV RNA包括前基因组RNA(pre-genomic RNA,pgRNA)及其剪切变异体,存在于病毒样颗粒或带有衣壳的抗体复合物中,这种结构也暗示了HBV RNA可以作为反映肝脏中cccDNA的存在和活性状态的一个指标。多项研究证实HBV RNA监测慢性乙型肝炎患者抗病毒疗效和预测停药后复发方面具有重要价值。故本文就血清HBV RNA相关的临床研究进展进行综述。
Chronic hepatitis B virus(HBV)infection leads to a range of liver-related diseases and poses a serious threat to health.The persistence and chronicity of HBV infection is closely related to the presence of covalently closed circular DNA(cccDNA)in the nuclei of hepatocytes.HBV RNA includes pre-genomic RNA(pgRNA)and its shear variants.The structure of HBV RNA,including pre-genomic RNA and its shear variants,which are present in virus-like particles or antibody complexes with capsids,also suggests that HBV RNA could be an indicator of the presence and activity status of cccDNA in the liver.Several studies have confirmed the value of HBV RNA in monitoring antiviral efficacy and predicting relapse after drug discontinuation in chronic hepatitis B patients.Therefore,this article summarized the progress of clinical studies related to serum HBV RNA.
作者
尹红静
胥莹
程霞
万岳梦
张帮婷
YIN Hongjing;XU Ying;CHENG Xia;WAN Yuemeng;ZHANG Bangting(Department of Gastroenterology,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China;Department of Laboratory Medicine,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China;Department of Critical Care Medicine,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)
出处
《胃肠病学和肝病学杂志》
2025年第9期1374-1377,1383,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
昆明医科大学2024年研究生创新基金(2024S90)。
