摘要
目的探讨胃组织CD36在胃癌患者预后预测中的意义。方法回顾性纳入152例2017年9月至2021年3月接受胃组织切除的进展期胃癌患者,随访2年。利用免疫组织化学染色评估CD36染色分数。利用Cox回归分析确定患者2年内复发、转移和死亡风险的独立预后因素。通过Kaplan-Meier分析构建生存曲线。通过时间依赖ROC曲线比较变量的预后预测能力。结果与癌旁组织相比,胃癌组织CD36染色分数显著升高(P=0.002)。根据胃癌特征分析,AJCC-8Ⅰ期至Ⅲ期胃癌组织CD36染色分数显著上升(组间P<0.001);浸润深度pT3、pT4较pT1、pT2的胃癌组织CD36染色分数显著升高(P<0.001);淋巴结转移患者胃癌组织CD36染色分数显著升高(P<0.001)。多因素Cox回归分析发现,CD36染色分数是胃癌患者术后2年内死亡、复发和转移的独立预后因素(P均<0.05)。Kaplan-Meier分析提示CD36染色分数≥5.0的患者术后2年内死亡、复发和转移风险显著升高(P均<0.05),且其预后预测能力优于传统标志物。结论胃癌组织CD36与恶性程度及预后有关,是进展期胃癌术后2年内死亡、复发和转移的预后因素。
Objective To investigate the prognostic significance of CD36 expression in gastric tissue for patients with advanced gastric cancer.Methods A retrospective study was conducted on 152 patients with advanced gastric cancer who underwent gastric tissue resection from Sep.2017 to Mar.2021,with a follow-up period of 2 years.Immunohistochemical staining was utilized to assess the CD36 staining score.Cox regression analysis was performed to identify independent prognostic factors for recurrence,metastasis,and mortality within 2 years.Kaplan-Meier analysis was employed to construct survival curves.The predictive ability of variables for prognosis was compared using time-dependent ROC curves.Results The CD36 staining score in gastric cancer tissues was significantly higher than that in adjacent tissues(P=0.002).Analysis based on characteristics of gastric cancer revealed a significant increase in the CD36 staining score from AJCC-8 stage Ⅰ to Ⅲ(intergroup P<0.001),as well as in pT3 and pT4 tumors compared to pT1 and pT2 tumors(P<0.001)and lymph node metastasis cases(P<0.001).Multivariate Cox regression analysis demonstrated that the CD36 staining score served as an independent prognostic factor for mortality,recurrence,and metastasis within 2 years after surgery(all P<0.05).Furthermore,Kaplan-Meier analysis indicated that patients with a CD36 staining score≥5.0 had a significantly higher risk of mortality,recurrence,and metastasis within 2 years after surgery(all P<0.05),exhibiting superior prognostic predictive ability compared to traditional markers.Conclusion Expression of CD36 in gastric cancer tissues is associated with malignancy degree and serves as an independent prognostic factor for mortality,recurrence,and metastasis within 2 years following surgery among patients with advanced gastric cancer.
作者
纪冰
陈晨
张蓉
沈琦
张烁
赵黎菁
王志荣
JI Bing;CHEN Chen;ZHANG Rong;SHEN Qi;ZHANG Shuo;ZHAO Lijing;WANG Zhirong(Department of Gastroenterology,Tongji Hospital Affiliated to Tongji University,Shanghai 200065;General Medical Ward,Jiangning Road Community Heal)
出处
《胃肠病学和肝病学杂志》
2025年第9期1290-1294,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
国家自然科学基金项目(82070636)
静安区中青年拔尖人才项目。
