摘要
类风湿关节炎(RA)是一种累及多关节的慢性自身免疫病,其软骨损伤不可逆且伴随关节功能障碍,严重影响患者生活质量和社会参与能力。现有临床RA治疗药物效果有限,需寻找新的治疗靶点。基因与RA密切相关,表观遗传是影响基因组产生表型的机制,具有可逆性和特异性,在RA中研究广泛。本文拟对表观遗传调控在RA软骨损伤发生发展中的作用机制进行综述,以期为RA临床治疗提供新的思路。
Rheumatoid arthritis(RA)is a chronic autoimmune disease involving multiple joints,with irreversible cartilage damage and joint dysfunction,which seriously affects quality of life and social participation of patients.At present,efficacy of clinical RA therapy drugs is limited,and new therapeutic targets need to be found.Genes are closely related to RA,and epigenetics is mecha-nism that affects phenotype of genome,it is reversible and specific,which has been widely studied in RA.This article aims to review mechanism of epigenetic regulation in occurrence and development of RA cartilage injury,in order to provide new ideas for clinical treatment of RA.
作者
罗煜
魏巍
杨馨
LUO Yu;WEI Wei;YANG Xin(School of Health Preservation and Rehabilitation,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《中国免疫学杂志》
北大核心
2025年第8期2025-2031,共7页
Chinese Journal of Immunology
基金
国家自然科学基金面上项目(81774435)。
关键词
类风湿关节炎
软骨损伤
表观遗传
Rheumatoid arthritis
Cartilage damage
Epigenetics
