摘要
缺血性脑卒中(CIS)作为一种高致残率、严重危害人类健康的疾病,其发病机制复杂,目前尚未完全阐明,急需探索新的有效的治疗措施。细胞焦亡作为炎症反应性的程序性细胞死亡模式,参与了CIS的发病机制,抑制CIS过程中的细胞焦亡、减轻炎症反应可有效缓解CIS脑损伤。祖国医学认为气虚血瘀是CIS的基础病机,益气活血法是治疗CIS的主要原则,故本文将细胞焦亡与气虚血瘀相关联,就通过益气活血法抑制细胞焦亡,减轻CIS脑组织损伤的研究进展进行如下综述。
Cerebral ischemic stroke(CIS)is a serious health hazard with a high disability rate.Its pathogenesis is complex and not yet fully understood,and new effective treatments need to be explored.The newly discovered pyroptosis,which is regarded as a programmed cell death mode of inflammatory response,is involved in the pathogenesis of CIS.Inhibiting cellular scorch death during CIS and reducing the inflammatory response can effectively alleviate CIS brain injury.According to traditional Chinese medicine,defi-ciency of Qi and stasis of blood are the fundamental pathogenesis of CIS.The method of benefiting Qi and activating blood is the main principle for treating CIS.Therefore,in this paper,we link cell pyroptosis with Qi deficiency and blood stasis,review the progress of research on reducing brain tissue damage in CIS by inhibiting pyroptosis through the method of benefiting Qi and invigorating blood.
作者
王泽超
张怡
张拴成
方敬
侯仙明
WANG Zechao;ZHANG Yi;ZHANG Shuancheng;FANG Jing;HOU Xianming(Hebei University of Chinese Medicine,Heibei Key Laboratory of Chinese Medicine Research on Cardio-cerebrovascular Disease,Shijiazhuang 050091,China)
出处
《中国免疫学杂志》
北大核心
2025年第8期2019-2024,共6页
Chinese Journal of Immunology
基金
国家自然科学基金青年基金项目(82104963)
河北省中医药管理局中医药科研计划项目(Z2022004,2022086)
河北省普通高等学校青年拔尖人才计划项目(BJ2020027)
河北中医学院优秀青年教师基础研究计划项目(YQ2020004)
河北中医学院博士科研基金项目(BSZ2020013)
河北省大学生创新创业训练计划项目(S202214432064)。
关键词
缺血性脑卒中
细胞焦亡
气虚血瘀
Cerebral ischemic stroke
Pyroptosis
Qi deficiency and blood stasis
Benefitting Qi and activating blood
