摘要
目的探讨重组人粒细胞-巨噬细胞集落刺激因子(recombinant human granulocyte-macrophage colony-stimulating factor,rhGM-CSF)联合双歧杆菌治疗化疗后口腔黏膜炎的临床疗效。方法选取2023年1月至2024年12月赣州市肿瘤医院收治的60例化疗后口腔黏膜炎患者为研究对象,采用随机数字表法分为观察组(n=30)与对照组(n=30)。对照组以rhGM-CSF含漱治疗,观察组增加双歧杆菌乳杆菌三联活菌胶囊口服。治疗2周后评估两组患者的临床疗效、症状评分、炎症因子水平、口腔微生态指标、治疗安全性。结果治疗后,观察组总有效率高于对照组(P<0.05);观察组患者的水肿、充血、溃疡评分和疼痛视觉模拟评分及炎症因子Toll样受体4、半乳糖凝集素-3、白细胞介素-8均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者的口腔微生态菌群包括乳酸菌、双歧杆菌高于对照组,牙龈卟啉单胞菌、福赛坦菌低于对照组,差异有统计学意义(P<0.05)。结论rhGM-CSF联合双歧杆菌治疗化疗后口腔黏膜炎的临床疗效显著,可减轻患者的各项症状,抑制炎症因子,改善口腔微生态,且治疗安全性良好。
Objective To investigate the clinical efficacy of recombinant human granulocyte-macrophage colony-stimulating factor(rhGM-CSF)combined with bifidobacterium in the treatment of oral mucositis after chemotherapy.Methods A total of 60 post-chemotherapy patients with oral mucositis admitted to Ganzhou Cancer Hospital of Jiangxi Province from January 2023 to December 2024 were selected as subjects,the patients were divided into observation group(n=30)and control group(n=30)by using a randomized digital table method.The control group received rhGM-CSF mouthwash treatment,while the observation group was additionally administered bifidobacterium-lactobacillus triple live capsules orally.Clinical efficacy,symptom scores,inflammatory factor levels,oral microbiota indicators,and treatment safety were evaluated after 2 weeks of treatment.Results After treatment,the total effective rate in observation group was significantly higher than that in control group(P<0.05).Post-treatment evaluations showed that patients in observation group exhibited lower scores for edema,congestion,and ulceration,along with reduced pain visual analog scores and decreased levels of inflammatory markers including Toll-like receptor 4,lectin-3,and interleukin-8,the difference were statistically significant(P<0.05).After treatment,the oral microecological flora of patients in observation group,including lactic acid bacteria and bifidobacterium,were higher than that of control group,while porphyromonas gingivalis and fusetella were lower than that of control group,the difference were statistically significant(P<0.05).Conclusion The clinical effect of rhGM-CSF combined with bifidobacterium in the treatment of oral mucositis after chemotherapy was significant,which could reduce various symptoms of patients,inhibit inflammatory factors,improve oral microecology,and have good safety.
作者
蓝清华
曾庆芳
肖威
詹涛
钟建明
邱流进
LAN Qinghua;ZENG Qingfang;XIAO Wei;ZHAN Tao;ZHONG Jianming;QIU Liujin(Lymphatic and Hematological Tumor Ward,Ganzhou Cancer Hospital of Jiangxi Province,Ganzhou 341000,Jiangxi,China;Department of Integrated Traditional Chinese and Western Medicine,Ganzhou Cancer Hospital of Jiangxi Province,Ganzhou 341000,Jiangxi,China)
出处
《中国现代医生》
2025年第23期50-53,共4页
China Modern Doctor
基金
江西省赣州市科技计划项目(20222ZDX8853)。
