摘要
目的:分析血清降钙素原(PCT)、淀粉酶(AMY)、白蛋白(ALB)、乳酸脱氢酶(LDH)及C-反应蛋白(CRP)水平在重症急性胰腺炎(SAP)早期诊断与病情评估中的价值。方法:选取急性胰腺炎(AP)患者120例为研究组,按照病情严重程度分为轻症组(38例)和重症组(82例)。选取同期体检健康者60例为对照组。比较研究组与对照组及轻症组与重症组血清PCT、AMY、ALB、LDH、CRP水平。Logistic回归分析SAP的影响因素,受试者工作特征(ROC)曲线分析血清PCT、AMY、ALB、LDH、CRP对SAP的早期诊断价值。结果:与对照组比较,研究组血清PCT、AMY、LDH、CRP水平更高,血清ALB水平更低(均P<0.05)。与轻症组比较,重症组血清PCT、AMY、LDH、CRP水平更高,血清ALB水平更低(均P<0.05)。血清高水平PCT、AMY、LDH、CRP及低水平ALB为SAP的影响因素(均P<0.05)。血清PCT、AMY、ALB、LDH、CRP水平及联合诊断早期SAP的曲线下面积(AUC)分别为0.775、0.813、0.761、0.792、0.747、0.930(均P<0.05)。结论:AP患者血清PCT、AMY、LDH、CRP水平升高,血清ALB水平降低,联合检测对SAP具有良好的早期诊断价值,且可用于病情严重程度评估。
Objective:To analyze the value of serum procalcitonin(PCT),amylase(AMY),albumin(ALB),lactate dehydrogenase(LDH)and C-reactive protein(CRP)levels in the early diagnosis and disease evaluation of severe acute pancreatitis(SAP).Methods:A total of 120 patients with acute pancreatitis(AP)were selected as the study group,and were divided into mild group(38 cases)and severe group(82 cases)according to the severity of the disease.Sixty healthy people were selected as the control group.The serum levels of PCT,AMY,ALB,LDH and CRP were compared between the study group and the control group,and between the mild group and the severe group.Logistic regression was used to analyze the influencing factors of SAP.The ROC curve was used to analyze the early diagnostic value of serum PCT,AMY,ALB,LDH and CRP in SAP.Results:Compared with control group,the serum levels of PCT,AMY,LDH and CRP in study group were higher,and the serum level of ALB was lower(all P<0.05).Compared with the mild group,serum PCT,AMY,LDH,CRP levels were higher,and serum ALB level was lower in severe group(all P<0.05).High levels of serum PCT,AMY,LDH,CRP and low level of serum ALB were influencing factors of SAP(all P<0.05).The AUC of serum PCT,AMY,ALB,LDH,CRP levels and their combination in the diagnosis of early SAP were 0.775,0.813,0.761,0.792,0.747,0.930,respectively(all P<0.05).Conclusion:The serum levels of PCT,AMY,LDH and CRP are increased and the serum level of ALB is decreased in AP patients.The combined detection has a good early diagnostic value for SAP and can be used to evaluate the severity of the disease.
作者
路璐
葛利丽
刘鹭
LU Lu;GE Lili;LIU Lu(Clinical Inspection Center,Huai’an Hospital Affiliated to Xuzhou Medical University,Huai’an 223002,China)
出处
《陕西医学杂志》
2025年第9期1203-1207,共5页
Shaanxi Medical Journal
基金
国家自然科学基金资助项目(81900216)
江苏省卫生健康委医学科学研究课题(2022HJK661)。
