摘要
目的探讨在冠心病不稳定型心绞痛患者中运用复方血栓通胶囊联合替格瑞洛治疗的效果,总结分析其对心功能的影响。方法从厦门长庚医院心内科2023年1月—2024年1月收治的所有冠心病不稳定型心绞痛患者中选取88例作为研究对象,按治疗方法不同分为观察组与对照组。对照组(n=44)给予替格瑞洛治疗,观察组(n=44)给予复方血栓通胶囊联合替格瑞洛治疗。比较2组临床疗效、心功能、不良反应发生率、生活质量评分。结果观察组总有效率为88.64%,高于对照组的70.45%,差异有统计学意义(P<0.05)。治疗后,观察组左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左室收缩末期内径(left ventricular end systolic diameter,LVESD)分别为(40.36±3.47)mm、(32.14±3.42)mm,均低于对照组的(46.72±4.15)mm、(36.83±4.59)mm;观察组左心室射血分数(left ventricular ejection fraction,LVEF)、Barthel指数(Barthel index,BI)评分分别为(48.58±8.24)%、(89.76±10.35)分,高于对照组的(42.60±9.32)%、(83.18±8.65)分,差异有统计学意义(P<0.05)。2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论在冠心病不稳定型心绞痛的治疗中运用复方血栓通胶囊联合替格瑞洛可以取得较为理想的效果,有助于更快缓解临床症状,稳定病情,并且可促进心功能好转,还能够改善预后,提高生活质量。
Objective To explore the effect of using compound Xueshuantong capsules combined with ticagrelor in the treatment of unstable angina pectoris in coronary heart disease,and to summarize and analyze its impact on cardiac function.Methods A total of 88 patients with unstable angina pectoris in coronary heart disease who were admitted to the department of cardiology of Xiamen Changgung Hospital from January 2023 to January 2024 were selected as the research subjects.According to different treatment methods,they were divided into the observation group and the control group.The control group(n=44)was treated with ticagrelor,while the observation group(n=44)was treated with compound Xueshuantong capsules combined with ticagrelor.The clinical efficacy,cardiac function,incidence of adverse reactions and quality of life scores of the two groups were compared.Results The total effective rate of the observation group was 88.64%,which was higher than 70.45%of the control group,and the difference between the two groups was statistically significant(P<0.05).After treatment,the left ventricular end diastolic diameter(LVEDD),the left ventricular end systolic diameter(LVESD)in the observation group was(40.36±3.47)mm,(32.14±3.42)mm,both of which were lower than(46.72±4.15)mm and(36.83±4.59)mm of the control group.The left ventricular ejection fraction(LVEF),Barthel index(BI)score of the observation group was(48.58±8.24)%,(89.76±10.35)points,which was higher than(42.60±9.32)%,(83.18±8.65)points of the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The use of compound Xueshuantong capsules combined with ticagrelor in the treatment of unstable angina pectoris in coronary heart disease can achieve ideal therapeutic effects,help to relieve clinical symptoms faster,stabilize the condition,promote cardiac function improvement,improve prognosis,and improve quality of life.
作者
宋宏宾
张冶
张一芝
SONG Hongbin;ZHANG Ye;ZHANG Yizhi(Department of Cardiology,Xiamen Changgung Hospital,Xiamen Fujian 361028,China)
出处
《中国卫生标准管理》
2025年第11期145-148,共4页
China Health Standard Management
关键词
冠心病
不稳定型心绞痛
复方血栓通胶囊
替格瑞洛
治疗效果
心功能
coronary heart disease
unstable angina pectoris
compound Xueshuantong capsules
ticagrelor
therapeutic effect
cardiac function
