摘要
目的 探讨中国老年人群中中国内脏脂肪指数(CVAI)与骨关节炎(OA)风险之间的关联性。方法 纳入2021年1月-2024年12月在喀什地区第一人民医院疼痛科住院的6521例患者,根据CVAI的四分位数将其分为Q1组(<118.97)、Q2组(118.97~141.36)、Q3组(141.36~164.09)以及Q4组(>164.09),比较各组一般及临床资料,使用多元Logistic回归分析CVAI与OA的相关性,通过工作特征曲线(ROC)对CVAI在OA诊断中的价值进行评估。结果 CVAI较高的个体通常年龄更大,女性占比更高,同时吸烟和饮酒的比例也更高(P<0.05)。CVAI较高组的TG和FPG水平较高,而TC、HDL-C和LDL-C水平则相对较低(P<0.05)。多元Logistic回归分析显示,CVAI与OA风险呈正相关(P<0.05)。在完全校正后的模型中,CVAI每增加10个单位,OA风险增加29%;与Q1组相比,Q4组的OA风险最高OR值为2.45。限制性立方样条(RCS)曲线结果表明,CVAI与OA风险呈现线性剂量-反应关系。ROC曲线下面积为0.75,提示CVAI具有较好的诊断能力;决策曲线分析(DCA)进一步证明其在临床预测中的实际应用价值。结论 CVAI与OA风险密切相关,可用于辅助诊疗OA。
Objective To explore the association between Chinese visceral adiposity index(CVAI)and the risk of osteoarthritis(OA)in Chinese elderly population.Methods A total of 6521 patients who were hospitalized in the pain department of the First People's Hospital of Kashgar Region from January 2021 to December 2024 were included.According to the quartile of CVAI,they were divided into Q1 group(164.09).The general and clinical data of each group were compared.Multivariate logistic regression was used to analyze the correlation between CVAI and OA.The value of CVAI in the diagnosis of OA was evaluated by working characteristic curve(ROC).Results Individuals with higher CVAI were usually older,had a higher proportion of women,and had a higher proportion of smoking and drinking(P<0.05).The levels of TG and FPG in the higher CVAI group were higher,while the levels of TC,HDL-C and LDL-C were relatively lower(P<0.05).Multivariate Logistic regression analysis showed that CVAI was positively correlated with OA risk(P<0.05).In the fully adjusted model,for every 10 units increase in CVAI,the risk of OA increased by 29%;compared with the Q1 group,the highest OR value of OA risk in the Q4 group was 2.45.The results of the restricted cubic spline(RCS)curve showed that CVAI and OA risk showed a linear dose-response relationship.The area under the ROC curve was 0.75,suggesting that CVAI had better diagnostic ability.Decision curve analysis(DCA)further proved its practical application value in clinical prediction.Conclusion CVAI is closely associated with OA risk,providing new insights into the role of visceral fat in the development and progression of OA.
作者
努丽比叶·吐鲁洪
麦麦提敏江·艾山
Nulibiye·Tuluhong;Maimaitiminjiang·Aishan(Department of Pain Management,the First People's Hospital of Kashgar Region,Kashgar 844000,Xinjiang,China)
出处
《医学信息》
2025年第17期88-92,共5页
Journal of Medical Information
基金
新疆维吾尔自治区自然科学基金(编号:2021D01C18)。
关键词
老年人群
中国内脏脂肪指数
骨关节炎
Elderly population
Chinese visceral adiposity index
Osteoarthritis
