摘要
肝纤维化(HF)是多种慢性肝病发展成肝硬化乃至肝癌的必经过程,超过80%的肝细胞癌都是在慢性肝炎、HF或肝硬化过程之后形成的,而炎症与纤维化所产生的免疫微环境对肝细胞癌的发生、发展有很大的推动作用。肝星状细胞(HSC)、细胞外基质(ECM)和成纤维细胞通过影响固有免疫和适应免疫,进而参与HF的进程。该文通过分析HF中免疫细胞的作用,以期为临床治疗HF提供新的干预途径和治疗靶点,从而进一步提升免疫治疗的有效率,为HF患者提供更安全、更有效的治疗选择。
Hepatic fibrosis(HF)is an inevitable process for many chronic liver diseases to develop into liver cirrhosis and even liver cancer.More than 80%of hepatocellular carcinomas are formed after the process of chronic hepatitis,HF or liver cirrhosis.The immune microenvironment produced by inflammation and fibrosis plays a significant role in promoting the occurrence and development of hepatocellular carcinoma.Hepatic stellate cells(HSC),extracellular matrix(ECM),and fibroblasts are involved in the progression of HF by influencing innate immunity and adaptive immunity.This article,by analyzing the role of immune cells in HF,is expected to provide new intervention approaches and therapeutic targets for the clinical treatment of HF,thereby further enhancing the effectiveness of immunotherapy and offering safer and more effective treatment options for HF patients.
作者
马文娟
杨旭国
帖振昱
张永茂
王贞香
MA Wenjuan;YANG Xuguo;TIE Zhenyu;ZHANG Yongmao;WANG Zhenxiang(School of Medicine,Hexi University,Zhangye,Gansu 734000,China)
出处
《重庆医学》
2025年第8期1936-1939,共4页
Chongqing Medical Journal
基金
甘肃省教育科技创新项目(2022B-205)
甘肃省大学生省级创新训练项目(S202410740065)
2024年河西学院校长基金项目(QN2024005,QN2024029)。
关键词
肝纤维化
细胞外基质
免疫细胞
靶向治疗
hepatic fibrosis
extracellular matrix
immune cells
targeted therapy
