摘要
阿尔茨海默病(AD)是一种在老年群体中频繁出现的神经退行性疾病,以痴呆为主要表现形式之一,其发病过程通常较为隐蔽,主要症状包括认知功能和行为的逐渐退化。细胞外β淀粉样蛋白(Aβ)的沉积和Tau蛋白在细胞内的过度磷酸化构成了AD的主要病理标志。睡眠剥夺(SD)是AD的重要发生因素,两者间存在着紧密联系,其机制可能与睡眠不足或睡眠节律改变导致Aβ沉积和Tau蛋白过度磷酸化、内分泌系统分泌异常、神经组织病变、载脂蛋白E基因表达异常等方面有关。通过研究SD与AD的关系,可以进一步了解睡眠在预防和治疗AD中的重要性。
Alzheimer's disease(AD)is a neurodegenerative disorder that occurs frequently in the elderly population,with dementia as one of its main manifestations.Its onset is typically insidious,characterized by progressive deterioration in cognitive function and behavior.Extracellular deposition of amyloidβ-protein(Aβ)and intracellular hyperphosphorylation of Tau protein constitute the principal pathological hallmarks of AD.Sleep deprivation(SD)is a significant risk factor for AD,and the two are closely interconnected.The underlying mechanisms may involve increased Aβdeposition and Tau hyperphosphorylation resulting from insufficient or rhythm-disrupted sleep,endocrine dysfunction,neural tissue damage,and aberrant expression of the apolipoprotein E gene.This study underscores the critical role of sleep regulation in AD prevention and therapeutic interventions through investigating the relationship between SD and AD.
作者
蒙美竹
莫开珍
谭萍
祝美珍
MENG Meizhu;MO Kaizhen;TAN Ping;ZHU Meizhen(Ruikang Clinical Medical College,Guangxi University of Chinese Medicine,Nanning 530000,Guangxi,China;College of Basic Medicine,Guangxi University of Chinese Medicine,Nanning 530000,Guangxi,China)
出处
《右江医学》
2025年第8期675-680,共6页
Chinese Youjiang Medical Journal
基金
国家自然科学基金(82460916)
广西中医药大学大学生创新创业项目(202310600208)。
关键词
阿尔茨海默病
睡眠剥夺
Β淀粉样蛋白
TAU蛋白
Alzheimer's disease(AD)
sleep deprivation(SD)
amyloidβ-protein(Aβ)
Tau protein
