摘要
报告前列腺癌患者口服阿帕他胺后诱发红皮病1例。患者男,73岁,因躯干和四肢红斑和鳞屑伴瘙痒2月余就诊。患者确诊前列腺癌半年,规律口服阿帕他胺片、中药等药物2个月后出现红色斑疹伴瘙痒,后融合成红色斑片,双下肢为重。皮肤科检查:躯干、四肢弥漫性红斑、鳞屑,超过体表面积90%。实验室检查提示嗜酸性粒细胞绝对值升高。第一次住院未停用阿帕他胺,停掉中药后给予激素、抗组胺药等治疗后好转,激素减量后皮损加重,第二次住院行组织病理检查示基底细胞液化变性,真皮淋巴细胞为主伴少量嗜酸性粒细胞浸润。考虑患者红皮病为阿帕他胺诱发。停用阿帕他胺,予激素治疗,皮损持续好转,现仍在随访中。
We report a case of erythroderma induced by apalutamide in a patient with prostate cancer.A 73-year-old man presented with pruritic erythema and scaling on the trunk and limbs for over two months.The patient was diagnosed with prostate cancer six months ago.After regularly taking apalutamide tablets,traditional Chinese medicine,and other medications for two months,he developed red rashes accompanied by itching,which later merged into red plaques,with the lower limbs being most affected.Dermatological examination revealed diffuse erythema and scaling on the trunk and limbs,covering more than 90%of the body surface area.Laboratory tests indicated an elevated absolute eosinophil count.During the first hospitalization,apalutamide was not discontinued,but traditional Chinese medicine was stopped.The patient was treated with corticosteroids and antihistamines,leading to improvement.However,the skin lesions worsened after tapering the corticosteroids.During the second hospitalization,histopathological examination showed liquefaction degeneration of basal cells and dermal lymphocytic infiltration with a small number of eosinophils.The patient′s erythroderma was considered to be induced by apalutamide.Apalutamide was discontinued and corticosteroid therapy was continued,resulting in sustained improvement of the skin lesions.The patient is still under follow-up.
作者
刘妍
李小红
白飞英
何依玹
LIU Yan;LI Xiaohong;BAI Feiying;HE Yixuan(First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《皮肤性病诊疗学杂志》
2025年第7期534-538,共5页
Journal of Diagnosis and Therapy on Dermato-venereology
关键词
红皮病
前列腺癌
阿帕他胺
apalutamide
erythroderma
prostate cancer
