摘要
氧化应激及其伴随的血管损伤和炎症等病理生理过程已被认为是许多眼部疾病的重要发病机制。山奈酚作为一种天然黄酮类化合物,凭借其显著的抗氧化、抗炎及抗血管生成活性,在多种眼病防治中展现出广阔前景。在干眼模型中,山奈酚可有效抑制眼表炎症,促进角膜修复并增加泪液分泌;在青光眼治疗中,其能够保护视网膜神经节细胞,减轻视神经损伤;在视网膜退行性疾病(如年龄相关性黄斑变性)中,山奈酚可保护视网膜色素上皮细胞,减轻氧化应激诱导的损伤和细胞凋亡;在眼部新生血管性疾病中(涵盖角膜、视网膜及脉络膜新生血管),山奈酚通过抑制关键促血管生成因子(如血管内皮生长因子)的表达及信号传导,有效阻断病理性新生血管的形成。山奈酚通过多靶点作用机制,对多种眼病具有重要的治疗潜力,其深入研究将为临床应用和创新药物开发提供科学依据。本文就山奈酚在眼科领域的最新研究进展进行综述。
Oxidative stress and its closely related pathophysiological processes of vascular damage and inflammation have been recognized as important pathogenic mechanisms in many ocular diseases.Kaempferol,a natural flavonoid compound,exhibits great promise in preventing and treating various eye disorders due to its potent antioxidant,anti-inflammatory,and anti-angiogenic activities.In dry eye models,kaempferol effectively suppresses ocular surface inflammation,promotes corneal repair,and increases tear secretion.In glaucoma treatment,kaempferol protects retinal ganglion cells and alleviates optic nerve damage.For retinal degenerative diseases,such as age-related macular degeneration,kaempferol protects retinal pigment epithelial cells from oxidative stress-induced damage and apoptosis.In ocular neovascular diseases,which encompass corneal,retinal,and choroidal neovascularization,kaempferol effectively blocks pathological neovascularization formation by inhibiting the expression and signaling of key proangiogenic factors,such as vascular endothelial growth factor.Kaempferol has significant therapeutic potential for multiple eye diseases through multi-target mechanisms,and its further research will provide a scientific basis for its clinical application and development of innovative therapeutics.This review summarizes recent advances in kaempferol research in ophthalmology.
作者
管文雪(综述)
孙摇遥
赵明威(审校)
Guan Wenxue;Sun Yaoyao;Zhao Mingwei(Department of Ophthalmology,Peking University People's Hospital,Beijing Key Laboratory of Ocular Disease and Optometry Science,Beijing 100044,China)
出处
《中华实验眼科杂志(中英文)》
北大核心
2025年第8期745-748,共4页
Chinese Journal Of Experimental Ophthalmology
基金
国家自然科学基金(82301211)。
关键词
山奈酚
眼部疾病
治疗
综述
Kaempferol
Ocular diseases
Treatment
Review
