摘要
慢性肾脏病(CKD)已成为全球范围内的重大公共卫生问题,除传统风险因素外,性别在CKD的发生和进展中也发挥着重要作用,涉及性激素与肾素-血管紧张素系统、氧化应激、炎症及血管疾病等生理途径之间的复杂相互作用。尽管女性CKD发病率较高,但男性往往更为迅速地进展为终末期肾病。与男性相比,绝经前后女性也可观察到疾病进展变化。然而,目前对CKD发病机制中性别差异的潜在机制仍知之甚少,包括性激素及其衍生物的作用,从而限制了个性化干预的应用。本文重点回顾性别差异对狼疮性肾炎、糖尿病肾病、IgA肾病等常见CKD发生和发展的影响。
Chronic kidney disease(CKD)is an important public health problem worldwide,with a significant global health burden.It is well known that,in addition to traditional risk factors,gender plays a key role in the development and progression of CKD,involving complex interactions of sex hormones with physiological pathways such as the renin-angiotensin system,oxidative stress,inflammation,and vascular disease.Despite the higher prevalence of CKD in women,men tend to progress more rapidly to end-stage renal disease.Changes in progression are also observed in pre-and post-menopausal women compared to men.The underlying mechanisms of gender differences in CKD pathogenesis,including the role of sex hormones and their derivatives,remain poorly understood,thus limiting their use in personalized interventions.This review focuses on the impact of gender differences on several types of renal diseases that primarily cause CKD,including lupus nephritis,diabetic nephropathy,IgA nephropathy,membranous nephropathy,and autosomal dominant polycystic kidney disease.
作者
高鸥(综述)
谢红浪(审校)
GAO Ou;XIE Honglang(National Clinical Research Center for Kidney Diseases,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210016,China)
出处
《肾脏病与透析肾移植杂志》
2025年第4期371-375,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
国家重点研发计划项目(2024YFC2511002)。
关键词
慢性肾脏病
性激素
激素替代治疗
chronic kidney disease
sex hormones
hormone replacement therapy
