摘要
糖尿病肾病(DN)是2型糖尿病最常见的并发症,发病机制复杂。蛋白翻译后修饰(PTM)是指蛋白质合成后通过共价键添加化学基团,从而改变其结构与功能的过程,包括乙酰化、丙二酰化、琥珀酰化、乳酸化等。关键蛋白的翻译后修饰,可影响细胞代谢重编程和关键信号通路,参与信号转导、周期调控和代谢调控等过程。越来越多的研究发现,多种PTM在DN肾脏固有细胞损伤、肾小管间质纤维化等病理过程中发挥重要作用。本文就PTM在DN发病机制中的研究进展作一综述。
Diabetic nephropathy(DN)is the most prevalent complication of type 2 diabetes mellitus,and is characterized by a complex pathogenesis.Post-translational modifications(PTM)refer to the processes by which chemical groups are covalently added to proteins following synthesis,thereby altering their structure and function.These modifications include acetylation,malonylation,succinylation,lactylation,among others.The PTMs of key proteins can significantly influence cellular metabolic reprogramming and critical signaling pathways,participating processes such as signal transduction,cycle regulation,and metabolic regulation.An increasing body of research has demonstrated that multiple PTMs play significant roles in the pathological processes of DN,including injury to intrinsic renal cells and tubulointerstitial fibrosis.This article reviews the research progress regarding the relationship between PTM and DN.
作者
张慧艳(综述)
蒋松(审校)
ZHANG Huiyan;JIANG Song(National Clinical Research Centre for Kidney Diseases,Jinling Hospital,Jinling Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing 210016,China)
出处
《肾脏病与透析肾移植杂志》
2025年第4期359-364,共6页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
国家自然科学基金面上项目(82370733)。
关键词
翻译后修饰
糖尿病肾病
乙酰化
丙二酰化
琥珀酰化
乳酸化
post-translational modification
diabetic nephropathy
acetylation
malonylation
succinylation
lactylation
