摘要
皮肤基底细胞癌(BCC)作为最常见的皮肤恶性肿瘤,发病率随人口老龄化而升高,少数病例可浸润转移,因此早期诊断和治疗至关重要。本文综述BCC的最新治疗进展,重点介绍多种治疗方案的特点及最新研究进展,包括莫氏手术、光动力疗法、冷冻治疗、局部药物治疗[如咪喹莫特、5-氟尿嘧啶(5-FU)、巨大戟醇甲基丁烯酸酯(IM)等]、放射治疗、激光治疗、靶向药物治疗[如Hedgehog通路抑制剂(HPI)、程序性死亡受体-1(PD-1)抑制剂等]及其他新兴治疗手段(如溶瘤肽、小干扰RNA药物),强调根据BCC的风险水平制定个体化治疗方案的重要性,并指出未来治疗将更加注重技术创新与多学科合作,以提升患者预后和生活质量。
As the most common malignant skin tumor,the incidence of basal cell carcinoma(BCC)is rising with population aging.Although most cases are localized,a small number may infiltrate or metastasize,making early diagnosis and treatment crucial.This article reviews recent advances in the treatment of cutaneous BCC,highlighting the characteristics and latest developments of various therapeutic approaches.These include Mohs micrographic surgery,photodynamic therapy,cryotherapy,topical medications such as imiquimod,5-fluorouracil(5-FU),ingenol mebutate(IM),radiotherapy,laser therapy,targeted drug therapies such as Hedgehog pathway inhibitors(HPI),and programmed death receptor-1(PD-1)inhibitors.Emerging treatments such as oncolytic peptides and small interfering RNA(siRNA)drugs are also discussed.The article emphasizes the importance of tailoring treatment strategies based on BCC risk levels and suggests that future therapies will focus more on technological innovation and multidisciplinary collaboration to improve patient outcomes and quality of life.
作者
张元林
孟秀梅
慈超
ZHANG Yuanlin;MENG Xiumei;CI Chao(Yijishan Hospital,Wannan Medical College,Wuhu 241000,China)
出处
《皮肤性病诊疗学杂志》
2025年第8期613-618,共6页
Journal of Diagnosis and Therapy on Dermato-venereology
基金
皖南医学院校重点科研基金(WK2024ZZD30)。
