摘要
目的观察男性雄激素性脱发患者外用重组17型胶原蛋白喷雾的应用效果。方法选取2024年9月至2024年12月河南科技大学第一附属医院皮肤科门诊30例男性雄激素性脱发患者,外用重组17型胶原蛋白喷雾,每天2次。12周后观察毛发生长情况和不良反应情况。结果12周后,患者毛发外观均有好转。应用前和应用12周后,毛发平均密度分别为(33.26±4.25)根/0.46 cm^(2)和(42.27±4.93)根/0.46 cm^(2),毛发平均直径分别为(50.20±4.91)μm和(57.93±3.96)μm,差异均有统计学意义(t值分别为5.53、4.78,均P<0.05)。患者自我评分认为应用后脱发有中度改善者占73.33%,有明显改善者占3.33%,总有效率为76.67%,所有患者均未发生严重不良反应。结论外用重组17型胶原蛋白喷雾能够改善雄激素性脱发患者的症状,促进毛发生长。
Objective To observe the effect of recombinant collagen 17 spray on male androgenic alopecia.Methods From September 2024 to December 2024,30 men with androgenic alopecia were treated with recombinant collagen 17 spray twice daily at the dermatology department of the First Affiliated Hospital of Henan University of Science and Technology.After 12 weeks of treatment,hair growth and adverse reactions were observed.Results After 12 weeks,the appearance of patients’hair improved.The average hair density was increased from 33.26±4.25 hairs/0.46 cm^(2) to 42.27±4.93 hairs/0.46 cm^(2),and the average hair diameter was from 50.20±4.91μm to 57.93±3.96μm(t=5.53 and 4.78,respectively;P<0.05 for both).According to patients’self-assessments,73.33%reported moderate improvement in hair loss after treatment,3.33%reported significant improvement,resulting in a total effective rate of 76.67%.No serious adverse reactions occurred in any patient.Conclusion Recombinant collagen 17 spray can improve androgenic alopecia and promote hair growth.
作者
尚智伟
夏丽晔
刘琳霞
汪文翠
SHANG Zhiwei;XIA Liye;LIU Linxia;WANG Wencui(First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)
出处
《皮肤性病诊疗学杂志》
2025年第8期567-570,共4页
Journal of Diagnosis and Therapy on Dermato-venereology
