摘要
目的:探讨急性淋巴细胞白血病患儿环磷酰胺(CTX)过敏的临床表现特点及脱敏方法。方法:分析2例急性淋细胞白血病患儿应用CTX过敏的临床表现、处理措施,并进行文献复习。结果:患儿1为6岁女童,于第6次CTX治疗后出现胸闷、憋气,予面罩吸氧、地塞米松5 mg,症状消失,后通过我院CTX分步输注成功脱敏。患儿2为9岁男童,于第2次CTX治疗后出现过敏表现。立即停止药物输注,并给予面罩吸氧、心电监护、肌注肾上腺素0.25 mL,静脉推注地塞米松5 mg,口服氯雷他定糖浆,患儿症状均消失,以CTX分步输注成功脱敏。结论:儿童急性淋巴细胞白血病CTX过敏多起病急,尽早处理过敏反应并选择合适的脱敏疗法是获得良好预后的关键。
Objective:To probe into the clinical characteristics and desensitization strategies for allergic reactions of cyclophosphamide(CTX)in children with acute lymphoblastic leukemia.Methods:Clinical manifestations and treatment for allergic reactions of CTX in two children with acute lymphoblastic leukemia were analyzed,and the literature were reviewed.Results:A 6-year-old girl developed chest tightness and dyspnea during the sixth CTX treatment.Symptoms were resolved after mask oxygen therapy and intravenous dexamethasone of 5 mg.Subsequent desensitization was achieved via a graded CTX infusion protocol.A 9-year-old boy developed allergic reactions during the second CTX treatment.Immediate interventions included drug discontinuation,mask oxygen,cardiac monitoring,intramuscular epinephrine of 0.25 mL,intravenous dexamethasone of 5 mg,and oral loratadine syrup.Symptoms were resolved and subsequent desensitization was achieved via a graded CTX infusion protocol.Conclusion:Allergic reactions of CTX in children with acute lymphoblastic leukemia typically presents with acute onset.Prompt allergic reaction management and tailored desensitization protocols are critical for optimal outcomes.
作者
李孜淙
孙妍
姜健
王程
王玲珍
Li Zicong;Sun Yan;Jiang Jian;Wang Cheng;Wang Lingzhen(The Affiliated Hospital of Qingdao University,Shandong Qingdao 266555,China)
出处
《儿科药学杂志》
2025年第9期52-55,共4页
Journal of Pediatric Pharmacy
