摘要
目的探讨胃癌诊断中肿瘤标志物[糖类抗原724(CA724)、癌胚抗原(CEA)、糖类抗原242(CA242)、糖类抗原199(CA199)]联合检验的应用价值。方法选取50例胃癌患者(设为恶性组)、50例胃部良性病变患者(设为良性组)、50例健康体检者(设为对照组),均进行肿瘤标志物(CA724、CEA、CA242、CA199)检验。比较三组肿瘤标志物水平,恶性组不同分期患者肿瘤标志物水平,肿瘤标志物单项检验与联合检验对胃癌的诊断效能(灵敏度、特异度、准确度)。结果恶性组CEA(21.55±5.38)ng/ml、CA199(80.94±15.46)U/ml、CA242(33.04±4.46)U/ml、CA724(37.20±3.85)U/ml均高于良性组的(4.67±1.02)ng/ml、(38.26±6.33)U/ml、(15.57±2.71)U/ml、(11.21±2.01)U/ml和对照组的(1.04±0.22)ng/ml、(5.47±1.23)U/ml、(3.36±0.43)U/ml、(2.67±0.37)U/ml,良性组均高于对照组,具有统计学意义(P<0.05)。恶性组Ⅲ~Ⅳ期患者的CEA(25.07±3.06)ng/ml、CA199(87.16±15.65)U/ml、CA242(35.66±5.33)U/ml、CA724(42.14±7.34)U/ml均显著高于Ⅰ~Ⅱ期的(16.69±5.72)ng/ml、(72.34±11.36)U/ml、(29.42±4.16)U/ml、(30.38±6.05)U/ml,具有统计学意义(P<0.05)。肿瘤标志物四项联合检验的灵敏度、特异度、准确度均高于CEA、CA199、CA242、CA724单项检验,具有统计学意义(P<0.05)。结论利用肿瘤标志物联合检验对胃癌患者进行诊断,其灵敏度、特异度、准确度均较高,且有助于判断胃癌分期,在临床上具有积极的诊断价值。
Objective To explore the application value of combined test of tumor markers[carbohydrate antigen 724(CA724),carcinoembryonic antigen(CEA),carbohydrate antigen 242(CA242),and carbohydrate antigen 199(CA199)]in the diagnosis of gastric cancer.Methods A total of 50 gastric cancer patients(designated as malignant group),50 patients with benign gastric lesions(designated as benign group),and 50 healthy individuals who underwent physical examinations(designated as control group)were selected.All study subjects underwent tumor marker testing,including CA724,CEA,CA242,and CA199.Comparison of the levels of tumor markers in the three groups,the levels of tumor markers in patients at different stages of the malignant group,and the diagnostic efficacy(sensitivity,specificity,and accuracy)of single and combined tests of tumor markers for gastric cancer.Results The malignant group had CEA of(21.55±5.38)ng/ml,CA199 of(80.94±15.46)U/ml,CA242 of(33.04±4.46)U/ml,and CA724 of(37.20±3.85)U/ml,which were higher than those in the benign group[(4.67±1.02)ng/ml,(38.26±6.33)U/ml,(15.57±2.71)U/ml,and(11.21±2.01)U/ml]and the control group[(1.04±0.22)ng/ml,(5.47±1.23)U/ml,(3.36±0.43)U/ml,and(2.67±0.37)U/ml].The benign group was higher than the control group,and there was statistical significance(P<0.05).In the malignant group,CEA(25.07±3.06)ng/ml,CA199(87.16±15.65)U/ml,CA242(35.66±5.33)U/ml,and CA724(42.14±7.34)U/ml of stageⅢ-Ⅳpatients were significantly higher than those of stageⅠ-Ⅱpatients[(16.69±5.72)ng/ml,(72.34±11.36)U/ml,(29.42±4.16)U/ml,and(30.38±6.05)U/ml],and there was statistical significance(P<0.05).The sensitivity,specificity and accuracy of the combined tests of four tumor markers were all higher than those of the single test of CEA,CA199,CA242 and CA724,and there was statistical significance(P<0.05).Conclusion The combined test of tumor markers for the diagnosis of gastric cancer patients can achieve high detection rates,sensitivity,specificity,and accuracy,and helps to determine the classification of gastric cancer.It has positive diagnostic value in clinical practice.
作者
李怀生
LI Huai-sheng(Laboratory Department,Yutai County People's Hospital,Jining 272300,China)
出处
《中国实用医药》
2025年第20期68-71,共4页
China Practical Medicine
关键词
胃癌
肿瘤标志物
诊断效果
Gastric cancer
Tumor markers
Diagnostic effect
