摘要
化疗相关口腔黏膜炎为化疗药物对口腔黏膜细胞的直接损伤导致的炎症反应,是肿瘤化疗后的常见不良反应之一,常表现为口腔黏膜糜烂、红斑和疼痛性溃疡性为主的急慢性口腔黏膜损伤。患者通常伴有明显疼痛,导致患者无法进食,甚至造成吞咽困难、味觉改变、体重减轻和继发感染的可能,影响患者生活质量。在更为严重的口腔黏膜炎中,会降低患者耐受最佳治疗方案的能力,甚至不得不延迟或终止继续化疗。该文总结了导致口腔黏膜炎的发生机制,免疫调节剂在治疗肿瘤化疗相关性口腔黏膜炎的研究进展,对于肿瘤化疗后诱导的口腔黏膜炎患者提高生活质量、减少感染和并发症、维持治疗计划的正常执行以及降低医疗成本具有重要的意义。
Chemotherapy-related oral mucositis is an inflammatory reaction resulting from the direct damage to oral mucosal cells caused by chemotherapy drugs.It is one of the most common adverse reactions following tumor chemotherapy.This condition often presents as acute and chronic oral mucosal erosion,erythema,and painful ulcers.Patients typically experience significant pain,which can hinder their ability to eat and may lead to difficulties in swallowing,alterations in taste,weight loss,and an increased risk of secondary infections,all of which negatively impact the patient's quality of life.In more severe cases of oral mucositis,patients'capacity to endure optimal treatment regimens is compromised,and the continuation of chemotherapy may need to be delayed or even discontinued.This article summarizes the mechanisms that contribute to the development of oral mucositis,the research advancements regarding immunomodulators in treating oral mucositis associated with tumor chemotherapy,and their role in enhancing the quality of life,reducing infections and complications,and maintaining treatment plans for patients suffering from oral mucositis induced by tumor chemotherapy.The effective management of this condition and the reduction of associated medical costs are of significant importance.
作者
李妍茸
王杰
陈超
LI Yanrong;WANG Jie;CHEN Chao(Department of General Surgery,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China)
出处
《现代肿瘤医学》
2025年第10期1802-1807,共6页
Journal of Modern Oncology
基金
国家自然科学基金面上项目(编号:81973625)
上海市中医医院第三届中医传承人才项目[编号:SZYCC(2023-2024)ZYCCXM03]
成都中医药大学“杏林学者”学科人才项目(编号:YYZX2022164)
上海西区中医联合体和上海市中医院分院2022年“未来计划”中医传承发展项目(编号:XBYLT-WLJH-2023-021)。
关键词
免疫抑制剂
口腔黏膜炎
化疗
机制
immunosuppressive agents
oral mucositis
chemotherapy
mechanism
