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8-异前列腺素F2α及OAHI在OSA患儿诊治中的应用进展

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摘要 阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)是一种常见的儿童睡眠障碍,主要表现为夜间反复的呼吸暂停和低通气事件。近年来,8-异前列腺素F2α作为一种生物标志物,在评估氧化应激和炎症方面显示出重要价值。OSA患儿体内的氧化应激水平显著增高,8-异前列腺素F2α的浓度与病情严重程度密切相关,提示其可能成为OSA的潜在诊断指标。阻塞性睡眠呼吸暂停低通气指数(obstructive apnea hypopnea index,OAHI)可帮助临床医生更好地识别高风险OSA患儿。此外,OAHI在OSA的治疗效果评估中也发挥着关键作用,尤其是在手术干预后,OAHI的变化可以反映气道功能的改善程度。本文作者就8-异前列腺素F2α及OAHI在OSA患儿诊断和治疗中的研究进展进行综述,为该病的临床管理提供新的思路。
出处 《东南大学学报(医学版)》 2025年第4期685-689,共5页 Journal of Southeast University(Medical Science Edition)
基金 梅州市科技计划项目(2022B26)。
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