摘要
目的分析三酰甘油葡萄糖-体质量指数(TyG-BMI)联合血清学指标对急性胰腺炎(AP)患者病情及预后的评估价值。方法选择2021年1月至2024年1月六安市人民医院收治的121例AP患者作为研究对象,按病情严重程度分为轻度AP组(n=84例)、中度AP组(n=19例)和重度AP组(n=18例),比较3组入院时的TyG-BMI和血清学指标[血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)和脂肪酶(LPS)]水平。采用Spearman相关性分析探讨TyG-BMI、SAA、CRP、LPS与AP患者病情严重程度的相关性。根据随访结果将患者分为预后良好组(n=80)和预后不良组(n=41),比较2组的TyG-BMI、SAA、CRP、LPS水平等临床资料。采用logistic回归分析探讨TyG-BMI、SAA、CRP、LPS与AP患者预后的关系。采用ROC曲线分析TyG-BMI、SAA、CRP、LPS对AP患者预后的预测价值。结果3组的TyG-BMI、SAA、CRP、LPS水平相比较,重度AP组分别显著高于中度AP组和轻度AP组(P均<0.05),中度AP组显著高于轻度AP组(P均<0.05)。Spearman相关性分析结果显示,TyG-BMI、SAA、CRP、LPS与AP患者病情严重程度均呈正相关(r=0.617、0.575、0.548、0.578,P均=0.000)。预后良好组的TyG-BMI、SAA、CRP、LPS水平均显著低于预后不良组(P均<0.05),预后良好组与预后不良组在病情严重程度方面的差异有统计学意义(P<0.05)。logistic回归分析结果显示,TyG-BMI、CRP、LPS、病情严重程度均为AP患者预后的危险因素(P<0.05)。ROC曲线分析结果显示,TyG-BMI、CRP、LPS、病情严重程度联合预测AP患者预后的AUC为0.993,分别显著大于各项单独预测(P均<0.05)。结论AP患者的TyG-BMI、SAA、CRP、LPS与AP病情严重程度均有相关性,且TyG-BMI、CRP、LPS、病情严重程度均为AP患者预后的危险因素,其可作为AP预后的联合预测指标。
Objective This paper intends to analyze the evaluation value of triglyceride glucose-body mass index combined with serum indicators for the severity and prognosis of patients with acute pancreatitis(AP).Methods A total of 121 patients with AP admitted to Lu’an People’s Hospital from January 2021 to January 2024 were selected and divided into the mild AP group(n=84),the moderate AP group(n=19),and the severe AP group(n=18)based on the severity of their condition.The TyG-BMI and serum indicators(serum amyloid A(SAA),C-reactive protein(CRP),and lipase(LPS))levels were compared among the three groups at admission.Spearman correlation analysis was used to explore the correlation between TyG-BMI,SAA,CRP,LPS and the severity of AP patients.Based on the follow-up results,the patients were further divided into the good prognosis group(n=80)and the poor prognosis group(n=41),and clinical data such as TyG-BMI,SAA,CRP,LPS levels were compared between the two groups.Logistic regression analysis was used to explore the relationship between TyG-BMI,SAA,CRP,LPS,and the prognosis of AP patients.ROC curve was used to evaluate the predictive value of TyG-BMI,SAA,CRP,and LPS for the prognosis of AP patients.Results The levels of TyG-BMI,SAA,CRP,and LPS of the severe AP group are significantly higher than that of the moderate AP group and the mild AP group(P<0.05),and those of the moderate AP group are significantly higher than that of the mild AP group(P<0.05).Spearman correlation analysis shows that TyG-BMI,SAA,CRP,LPS are positively correlated with the severity of AP(r=0.617,0.575,0.548,0.578,P=0.000).The levels of TyG-BMI,SAA,CRP,and LPS in the good prognosis group are significantly lower than those in the poor prognosis group(P<0.05),and there is a statistically significant difference in the severity of AP between the good prognosis group and the poor prognosis group(P<0.05).Logistic regression analysis indicates that TyG-BMI,CRP,LPS,and severity of AP are risk factors for prognosis in AP patients(P<0.05).ROC curve analysis suggests that the AUC of the combined prediction of TyG-BMI,CRP,LPS,and severity of AP for the prognosis of AP patients is 0.993,which is significantly higher than each individual prediction(P<0.05).Conclusion TyG-BMI,SAA,CRP,and LPS in AP patients are correlated with the severity of AP,while TyG-BMI,CRP,LPS,and severity of AP are risk factors for the prognosis of AP patients,which can serve as joint predictive indicators for AP prognosis.
作者
吕梅
余兰兰
张晓玲
LYU Mei;YU Lanlan;ZHANG Xiaoling(Department of Emergency Surgery,Lu’an People’s Hospital,Lu’an 237000,China)
出处
《国际消化病杂志》
2025年第4期273-278,共6页
International Journal of Digestive Diseases
