摘要
目的:探讨益生菌辅助治疗对老年心力衰竭(HF)患者的疗效及免疫功能的影响。方法:选取103例老年HF患者为研究对象,依据治疗方案不同分为联合组(n=52)及对照组(n=51)。对照组患者给予标准化HF治疗;联合组患者在对照组治疗基础上联合口服益生菌辅助治疗,疗程均为3个月。比较两组患者心功能、免疫功能、营养状况、运动功能及生活质量。结果:治疗后,两组患者舒张早期与晚期二尖瓣血流峰值比值(E/A)、左心室射血分数(LVEF)均升高(P<0.05),且联合组高于对照组(P<0.05);左心室收缩末期直径(LVESD)均降低(P<0.05),且联合组低于对照组(P<0.05);血清N末端脑利钠肽原(NT-proBNP)水平均降低(P<0.05),且联合组低于对照组(P<0.05);免疫球蛋白G(IgG)、IgA、IgM水平、微营养评定法-简表(MNA-SF)评分均升高(P<0.05),且联合组高于对照组(P<0.05);6 min步行试验(6MWT)距离均增加(P<0.05),且联合组高于对照组(P<0.05);明尼苏达州心力衰竭生活质量问卷(MLHFQ)评分均降低(P<0.05),且联合组低于对照组(P<0.05)。结论:益生菌辅助治疗可有效改善老年HF患者心功能、免疫功能及营养状况,且该联合治疗方案对于提升HF患者运动功能及生活质量具有积极意义。
Objective:To investigate the effect of probiotic adjuvant therapy on efficacy and immune function in elderly patients with heart failure(HF).Methods:103 elderly HF patients was selected and divided into a combination group(n=52)and a control group(n=51)according to different treatment methods.The control group received standard HF therapy,whereas the combination group received adjunctive oral probiotic adjuvant on the basis of the control group.Following 3 months of continuous intervention,parameters including cardiac function,immunological profiles,nutritional status,exercise tolerance,and quality of life were compared between the groups.Results:After treatment,the ratio of early to late diastolic mitral inflow peak velocities(E/A)and left ventricular ejection fraction(LVEF)in both groups were higher than those of before treatment(P<0.05),and the combination group was higher than the control group(P<0.05).The left ventricular end-systolic diameter(LVESD),N-terminal pro-brain natriuretic peptide(NT-proBNP)levels in both groups decreased(P<0.05),and the combination group was lower than the control group(P<0.05).Immunoglobulin G(IgG),IgA,IgM levels,and Mini Nutritional Assessment-Short Form(MNA-SF)scores in both groups were higher than those of before treatment(P<0.05),the combination group was higher than the control group(P<0.05).The 6-minute walk test(6MWT)distance in both groups was greater than that of before treatment(P<0.05),with the combination group showed a longer distance than the control group(P<0.05).The Minnesota Living with Heart Failure Questionnaire(MLHFQ)scores in both groups were lower than before treatment(P<0.05),with the combination group showed lower scores than the control group(P<0.05).Conclusion:Probiotic adjuvant therapy effectively improves cardiac function,immune status,and nutritional parameters in elderly HF patients.Additionally,this combined regimen demonstrates positive clinical significance in enhancing exercise capacity and quality of life in HF patients.
作者
刘玉
徐小红
杨诺言
曾子康
LIU Yu;XU Xiao-hong;YANG Nuo-yan;ZENG Zi-kang(Department of Cardiovascular Medicine,the Affiliated Chuzhou Hospital of Anhui Medical University,Chuzhou 239000;Bengbu Medical University,Bengbu 233030;Anhui Medical University,Hefei 230022,Anhui,China)
出处
《川北医学院学报》
2025年第8期1001-1005,共5页
Journal of North Sichuan Medical College
基金
安徽省自然科学基金项目(2008085QH371)。
关键词
益生菌
标准化抗心力衰竭治疗
心力衰竭
心功能
免疫功能
营养状况
Probiotics
Standardized anti-heart failure therapy
Heart failure
Cardiac function
Immune function
Nutritional status
