摘要
目的探讨同步抗感染治疗非酒精性脂肪性肝病合并幽门螺杆菌(Hp)感染患者的效果及对肠道微生态的影响。方法选取2017年1月至2021年12月就诊的200例非酒精性脂肪性肝病合并Hp感染患者为研究对象,根据随机数字表法将其分为对照组和同步组,各100例。对照组采用常规保肝治疗,同步组在对照组基础上增加抗感染治疗。比较两组的治疗效果。结果同步组的治疗总有效率高于对照组(P<0.05)。治疗后,两组的核因子κB(NF-κB)、C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-33(IL-33)水平低于治疗前,白细胞介素-35(IL-35)水平高于治疗前,且同步组优于对照组(P<0.05)。治疗后,两组的双歧杆菌、乳酸杆菌、消化链球菌数量多于治疗前,肠球菌、肠杆菌、酵母样菌数量少于治疗前,且同步组优于对照组(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论同步抗感染治疗非酒精性脂肪性肝病合并Hp感染患者的效果显著,可改善炎症因子水平,维持肠道微生态平衡,且不会增加不良反应。
Objective To investigate the effect of synchronous anti-infection treatment on patients with non-alcoholic fatty liver disease complicated with Helicobacter pylori(Hp)infection and its influence on intestinal microecology.Methods A total of 200 patients with non-alcoholic fatty liver disease complicated with Hp infection who were treated in our hospital from January 2017 to December 2021 were selected as the research objects.According to the random number table method,the patients were divided into control group and synchronous group,with 100 cases in each group.The control group was treated with conventional liver protection therapy,and the synchronous group was treated with anti-infective therapy on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the synchronous group was higher than that in the control group(P<0.05).After treatment,the levels of nuclear factor-κB(NF-κB),C-reactive protein(CRP),procalcitonin(PCT)and interleukin-33(IL-33)in the two groups were lower than those before treatment,and the level of interleukin-35(IL-35)was higher than that before treatment,and those in the synchronous group were better than the control group(P<0.05).After treatment,the numbers of Bifidobacterium,Lactobacillus and Peptostreptococcus in the two groups were more than those before treatment,and the numbers of Enterococcus,Enterobacter and Yeast-like bacteria were less than those before treatment,and those in the synchronous group were better than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Synchronous anti-infection treatment has a significant effect on patients with non-alcoholic fatty liver disease complicated with Hp infection,which can improve the level of inflammatory factors,maintain the intestinal microecological balance,and without increasing adverse reactions.
作者
刘玉涛
王艳妮
白胜江
LIU Yutao;WANG Yanni;BAI Shengjiang(Yan'an University Affiliated Hospital,Yan'an 716000;the Third Hospital of Yulin,Yulin 719000,China)
出处
《临床医学研究与实践》
2025年第25期70-73,共4页
Clinical Research and Practice
关键词
非酒精性脂肪性肝病
幽门螺杆菌
同步抗感染治疗
肠道微生态
non-alcoholic fatty liver disease
Helicobacter pylori
synchronous anti-infection treatment
intestinal microecological
