摘要
微血管衰老是一种与年龄增长相关的复杂生理过程。微血管内皮细胞的衰老及其功能障碍是微血管衰老的重要标志,表现为炎症因子表达增加、氧化应激加剧和微血管结构损伤。微血管衰老与老年糖尿病和心血管疾病等老年疾病密切相关,影响老年人的生活质量和健康。反应性高血流指数、循环内皮祖细胞和细胞外微泡等生物标志物在评估微血管健康和预测心血管事件方面具有重要意义。针对微血管衰老的干预措施,包括调整生活方式、药物治疗和靶向微血管结构和微血管内皮细胞功能的干预措施具有延缓或逆转微血管衰老的潜力。
Microvascular aging is a complex physiological process associated with advancing age.The aging and dysfunction of microvascular endothelial cells serve as critical markers of this phenomenon,characterized by increased expression of inflammatory factors,heightened oxidative stress,and structural damage to the microvasculature.This process is closely linked to age-related diseases such as diabetes in the elderly and cardiovascular disorders,significantly impacting the quality of life and overall health of older adults.Biomarkers,including the reactive hyperemia index,circulating endothelial progenitor cells,and extracellular microvesicles,play a vital role in assessing microvascular health and predicting cardiovascular events.Interventions targeting microvascular aging,which encompass lifestyle modifications,pharmacotherapy,and strategies aimed at preserving microvascular structure and endothelial cell function,hold promise for delaying or reversing the process of microvascular aging.
作者
刘炜琦
王影雨
刘明明
Liu Weiqi;Wang Yingyu;Liu Mingming(Institute of Microcirculation,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100005,China;International Center of Microvascular Medicine,Chinese Academy of Medical Sciences,Beijing 100005,China;Diabetes Research Center,Chinese Academy of Medical Sciences,Beijing 100005,China)
出处
《中华老年医学杂志》
北大核心
2025年第8期1149-1155,共7页
Chinese Journal of Geriatrics
基金
中国医学科学院医学与健康科技创新工程项目(2022-I2M-1-026)
北京市自然科学基金(7212068)
关键词
微血管衰老
微血管内皮细胞
老年糖尿病
炎症因子
氧化应激
Microvascular aging
Microvascular endothelial cells
Aging-related diabetes
Inflammatory mediators
Oxidative stress
